D0536 | malate
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | competitive inhibitor | 79 | ||||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Warning |
Aggregated GHS information provided by 1962 companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 7 of 1962 companies. For more detailed information, please visit ECHA C&L website Of the 20 notification(s) provided by 1955 of 1962 companies with hazard statement code(s): H315 (84.14%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (94.07%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
Aggregated GHS information provided by 321 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (13.08%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (57.94%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (17.13%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (82.87%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (13.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Warning |
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] |
P264, P280, P305+P351+P338, and P337+P313; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H315: Causes skin irritation [Warning Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] |
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Warning |
H315: Causes skin irritation [Warning Skin corrosion/irritation] H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] |
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LDLo | oral | 5500mg/kg (5500mg/kg) | Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923. | |
| rabbit | LDLo | subcutaneous | 5gm/kg (5000mg/kg) | Biochemische Zeitschrift. Vol. 123, Pg. 231, 1921. | |
| (+-)-1-Hydroxy-1,2-ethanedicarboxylic acid | (+-)-Hydroxysuccinic acid | (+-)-Malic acid |
| (+/-)-2-Hydroxysuccinic acid | (+/-)-HYDROXYBUTANEDIOIC ACID | (+/-)-HYDROXYSUCCINIC ACID |
| (+/-)-Malic acid | (-)-Malic acid | (R)-Hydroxybutanedioic acid |
| (S)-Hydroxybutanedioic acid | .+-.-Malic acid | 0C9A2DC0-FEA2-4864-B98B-0597CDD0AD06 |
| 17482-42-7 | 2-HYDROXY-SUCCINIC ACID | 2-Hydroxybutanedioic acid |
| 2-Hydroxydicarboxylic acid | 2-Hydroxyethane-1,2-dicarboxylate | 2-Hydroxyethane-1,2-dicarboxylic acid |
| 2-Hydroxysuccinate | 2-Hydroxysuccinic acid | 2-hydroxy-butanedioic acid |
| 2-hydroxyl-succinic acid | 21177-EP2314295A1 | 617-48-1 |
| 6915-15-7 | 78644-42-5 | 92310-EP2305257A1 |
| 99-EP2269610A2 | 99-EP2269983A1 | 99-EP2269984A1 |
| 99-EP2269986A1 | 99-EP2269988A2 | 99-EP2269989A1 |
| 99-EP2269990A1 | 99-EP2270006A1 | 99-EP2270008A1 |
| 99-EP2270011A1 | 99-EP2270014A1 | 99-EP2270505A1 |
| 99-EP2272516A2 | 99-EP2272827A1 | 99-EP2272835A1 |
| 99-EP2272844A1 | 99-EP2275401A1 | 99-EP2275404A1 |
| 99-EP2275411A2 | 99-EP2275413A1 | 99-EP2277848A1 |
| 99-EP2277858A1 | 99-EP2281559A1 | 99-EP2281563A1 |
| 99-EP2281819A1 | 99-EP2284160A1 | 99-EP2284169A1 |
| 99-EP2287155A1 | 99-EP2287156A1 | 99-EP2287160A1 |
| 99-EP2287161A1 | 99-EP2287162A1 | 99-EP2289510A1 |
| 99-EP2289879A1 | 99-EP2289883A1 | 99-EP2289890A1 |
| 99-EP2292612A2 | 99-EP2292617A1 | 99-EP2292619A1 |
| 99-EP2295401A2 | 99-EP2295402A2 | 99-EP2295406A1 |
| 99-EP2295433A2 | 99-EP2298731A1 | 99-EP2298746A1 |
| 99-EP2298747A1 | 99-EP2298755A1 | 99-EP2298757A2 |
| 99-EP2298768A1 | 99-EP2298772A1 | 99-EP2298778A1 |
| 99-EP2298779A1 | 99-EP2301544A1 | 99-EP2301922A1 |
| 99-EP2301931A1 | 99-EP2301937A1 | 99-EP2301940A1 |
| 99-EP2305219A1 | 99-EP2305248A1 | 99-EP2305257A1 |
| 99-EP2305633A1 | 99-EP2305641A1 | 99-EP2305646A1 |
| 99-EP2305651A1 | 99-EP2305659A1 | 99-EP2305663A1 |
| 99-EP2305672A1 | 99-EP2305673A1 | 99-EP2305679A1 |
| 99-EP2308839A1 | 99-EP2308849A1 | 99-EP2308850A1 |
| 99-EP2308854A1 | 99-EP2308857A1 | 99-EP2308869A1 |
| 99-EP2311809A1 | 99-EP2311810A1 | 99-EP2311811A1 |
| 99-EP2311814A1 | 99-EP2311818A1 | 99-EP2311834A1 |
| 99-EP2311842A2 | 99-EP2314295A1 | 99-EP2314574A1 |
| 99-EP2314584A1 | 99-EP2314585A1 | 99-EP2314586A1 |
| 99-EP2314588A1 | 99-EP2316457A1 | 99-EP2316458A1 |
| 99-EP2316459A1 | 99-EP2316825A1 | 99-EP2316826A1 |
| 99-EP2316827A1 | 99-EP2316828A1 | 99-EP2316831A1 |
| 99-EP2371802A1 | 99-EP2372017A1 | A19426 |
| AB00443952-12 | AB1002000 | ACMC-1B8G6 |
| ACN-S004262 | AI3-06292 | AK-65243 |
| AK-77850 | AK-88657 | AKOS000120085 |
| AKOS017278471 | AM81418 | ANW-43712 |
| Aepfelsaeure | BDBM92495 | BJEPYKJPYRNKOW-UHFFFAOYSA-N |
| BUTANEDIOIC ACID, HYDROXY-, (S)- | Butanedioic acid, (.+-.)- | Butanedioic acid, 2-hydroxy-, (2S)- |
| Butanedioic acid, hydroxy- | Butanedioic acid, hydroxy-, homopolymer | C00711 |
| C03668 | CAS-6915-15-7 | CCRIS 2950 |
| CCRIS 6567 | CHEBI:6650 | CHEMBL1455497 |
| CS-0017784 | CTK2F3631 | Caswell No. 537 |
| Certified Reference Material | D04843 | DB-016133 |
| DB12751 | DL(+/-)-MALIC ACID | DL-2-Hydroxybutanedioic acid |
| DL-2-hydroxybutanedioic acid | DL-Apple Acid | DL-Apple acid |
| DL-HYDROXYSUCOINIC ACID | DL-HYROXYBUTANEDIOIC ACID | DL-Hydroxysuccinic acid |
| DL-Malate | DL-Malic acid, 99% | DL-Malic acid, 99+% |
| DL-Malic acid, >=98% (capillary GC) | DL-Malic acid, >=99% | DL-Malic acid, FCC, >=99% |
| DL-Malic acid, ReagentPlus(R), 99% | DL-Malic acid, ReagentPlus(R), >=99% | DL-Malic acid, SAJ first grade, >=99.0% |
| DL-Malic acid, USP, 99.0-100.5% | DL-Malic acid, Vetec(TM) reagent grade, 98% | DL-Malic acid, analytical standard |
| DL-Malic acid, meets analytical specification of FCC, E296, 99-100.5% (alkalimetric); | DL-hydroxysuccinic acid | DL-malic acid |
| DSSTox_CID_7640 | DSSTox_GSID_27640 | DSSTox_RID_78538 |
| DTXSID0027640 | Deoxytetrarate | Deoxytetraric acid |
| E 296 | E-296 | E296 |
| EC 210-514-9 | EC 230-022-8 | EINECS 210-514-9 |
| EINECS 230-022-8 | EPA Pesticide Chemical Code 051101 | EU-0067046 |
| F0918-0088 | FDA 2018 | FEMA No. 2655 |
| FEMA Number 2655 | FT-0625484 | FT-0625485 |
| FT-0625539 | FT-0632189 | GTPL2480 |
| H2mal | HMS2358H06 | HMS3371C13 |
| HSDB 1202 | HY-Y1311 | Hydroxy Succinic Acid |
| Hydroxybutandisaeure | Hydroxybutanedioate | Hydroxybutanedioic acid homopolymer |
| Hydroxybutanedioic acid, (+-)- | Hydroxysuccinate | INS NO. 296 |
| INS NO.296 | INS-296 | KS-00000X4Q |
| KSC353M3D | Kyselina hydroxybutandiova | Kyselina hydroxybutandiova [Czech] |
| Kyselina jablecna | Kyselina jablecna [Czech] | L-(-)-MalicAcid |
| L023999 | LS-2394 | LS-88709 |
| M-0825 | M0020 | MALIC ACID,(DL) |
| MCULE-5852208511 | MFCD00064212 | MLS000084707 |
| Malate homopolymer | Malic acid (NF) | Malic acid L-(-)-form |
| Malic acid [NF] | Malic acid, DL- | Malic acid, L- |
| Malic acid, Pharmaceutical Secondary Standard | Malic acid, United States Pharmacopeia (USP) Reference Standard | Malic acid, meets USP/NF testing specifications |
| Malic acid-, (L-form)- | Malicacid | Malicum acidum |
| Monohydroxybernsteinsaeure | Musashi-no-Ringosan | NCGC00043225-02 |
| NCGC00043225-03 | NCGC00254259-01 | NCGC00259086-01 |
| NSC 25941 | NSC 9232 | NSC-25941 |
| NSC-9232 | NSC25941 | Opera_ID_805 |
| Oprea1_130558 | Oprea1_624131 | Poly (L-malate) |
| Poly(malate) | Pomalus acid | PubChem20057 |
| Q-201028 | Q190143 | R,S(+-)-Malic acid |
| R,S-Malate | R,S-Malic acid | R,SMalate |
| R,SMalic acid | R-Malic acid | RTR-037502 |
| Racemic malic acid | SC-19305 | SC-43909 |
| SCHEMBL856 | SMR000019054 | ST24046654 |
| STL283959 | STR03457 | SY003313 |
| SY009804 | Succinic acid, hydroxy- | TR-037502 |
| Tox21_201536 | Tox21_300372 | Z940713496 |
| a-Hydroxysuccinate | a-Hydroxysuccinic acid | alpha-Hydroxysuccinate |
| alpha-Hydroxysuccinic acid | bmse000046 | bmse000904 |
| butanedioic acid, 2-hydroxy- | dl-Hydroxybutanedioic acid | hydroxybutanedioic acid |
| hydroxysuccinic acid | malate | malic acid |
| s9001 |