Compound
D1278 | ionomycin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| TRANSPORT OF PROTONS BUT NOT CHARGE (CA2+ OR MG2+) | affect | 201 | ||||||
| TRANSPORT OF PROTONS BUT NOT CHARGE (CA2+ OR MG2+) | rat | liver mitochondria | Efflux of mitochondrial Mg2+ was determined by dual wavelength spectroscopy in the presence of 100 PM Eriochrome Blue SE, an indicating dye for free Mg | affect | 202 | |||
| OXYGEN CONSUMPTION RATE (OCR) | rat | liver mitochondria | Oxygen consumption and medium pH were monitored simultaneously with a dual channel Gilson oxygraph equipped with a Clark electrode (Yellow Springs Instruments) and a combination pH electrode (Beckman No. 39030). | increase | 202 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 42 companies from 1 notifications to the ECHA C&L Inventory. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | subcutaneous | 28mg/kg (28mg/kg) | Journal of Antibiotics. Vol. 31, Pg. 815, 1978. | |
| (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid | 54V905V6AT |
| 56092-81-0 | AKOS024456942 | AS-56129 |
| C41H72O9 | CHEBI:63954 | CHEMBL501617 |
| CS-0006887 | DTXSID2040521 | HMS3403I13 |
| HSCI1_000207 | HY-13434 | Ionomycin free acid |
| Ionomycin from Streptomyces conglobatus, >=98% (HPLC) | Ionomycin, Free Acid, Streptomyces conglobatus | Ionomycin, Free Acid, Streptomyces conglobatus in Solution |
| MFCD06798385 | SCHEMBL17265597 | UNII-54V905V6AT |
| X6869 | ZINC169289396 | ionomycin |
| CAS Number | 56092-81-0 |
| PubChem Compound | 6912226 |