Compound

D1290 | alpha-4-Dibromoacetophenone

Molecular Formula C8H6Br2O
Molecular Weight 277.94
Structure
Description GSK3beta inhibitor

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIA TRANSPORT 0.05 μM 2h rat Hippocampal Neurons time-lapse imaging experiments increase paired t-test; p < 0.02 215

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 46 companies from 4 notifications to the ECHA C&L Inventory.


H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 intravenous 18mg/kg (18mg/kg) U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02407,
mouse LD50 oral > 2gm/kg (2000mg/kg) Medicina Experimentalis. Vol. 11, Pg. 137, 1964.


  • CAS Number 132309-76-3, 99-73-0
    PubChem Compound 7454