MITOTOX

Drug

D1300 | mannitol

Molecular Formula	C6H14O6
Molecular Weight	182.17
Structure
State	solid
Route of elimination	It is rapidly excreted in the urine.
Protein binding	None
Half life	100 minutes
Absorption	Approximately 7% of ingested mannitol is absorbed during gastrointestinal perfusion in uremic patients.
Description	osmotic diuretic that is metabolically inert in humans

V04CX04 Mannitol

[V04CX] Other diagnostic agents

[V04C] OTHER DIAGNOSTIC AGENTS

[V04] DIAGNOSTIC AGENTS

[V] Various ATC structures

R05CB16 Mannitol

[R05CB] Mucolytics

[R05C] EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS

[R05] COUGH AND COLD PREPARATIONS

[R] Respiratory system

B05CX04 Mannitol

[B05CX] Other irrigating solutions

[B05C] IRRIGATING SOLUTIONS

[B05] BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

[B] Blood and blood forming organs

B05BC01 Mannitol

[B05BC] Solutions producing osmotic diuresis

[B05B] I.V. SOLUTIONS

[B05] BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

[B] Blood and blood forming organs

A06AD16 Mannitol

[A06AD] Osmotically acting laxatives

[A06A] DRUGS FOR CONSTIPATION

[A06] DRUGS FOR CONSTIPATION

[A] Alimentary tract and metabolism

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
MITOCHONDRIA TRANSPORT	200 mM			Neurons derived from the dorsal root ganglia of embryonic-day-14 (E14) chicken embryos	time-lapse microscopy, Kymograph	decrease		219

Organism	Test type	Route	Dose (normalized dose)	Source
man	TDLo	intravenous	5714mg/kg (5714mg/kg)	Nephron. Vol. 45, Pg. 233, 1987.
rat	LD50	intravenous	9690mg/kg (9690mg/kg)	Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.
rat	LD50	oral	13500mg/kg (13500mg/kg)	Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.
mouse	LD50	intraperitoneal	14gm/kg (14000mg/kg)	Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 98, 1936.
man	TDLo	intravenous	17143mg/kg/2D (17143mg/kg)	Archives of Internal Medicine. Vol. 144, Pg. 2053, 1984.
mouse	LD50	intravenous	7470mg/kg (7470mg/kg)	Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.
rat	LD50	intravenous	25800uL/kg (25.8mL/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
mouse	LD50	oral	22gm/kg (22000mg/kg)	FAO Nutrition Meetings Report Series. Vol. 40, Pg. 160, 1967.