D1320 | Melittin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| ATP SYNTHESIS | 5μM and 16μM | bovine | bovine heart MF1-ATPase | IC50 | 170 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P280, P301+P312, P302+P352, P312, P322, P330, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal] H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intraperitoneal | 2750ug/kg (2.75mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| rat | LDLo | intravenous | 1400ug/kg (1.4mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| rat | LD50 | intraperitoneal | 17700ug/kg (17.7mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| mouse | LD50 | intraperitoneal | 7400ug/kg (7.4mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| mouse | LD50 | intravenous | 7040ug/kg (7.04mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| 20449-79-0 | 24VT8NVE75 | 37231-28-0 |
| AKOS024456456 | Bee venom melittin | CHEBI:6736 |
| CHEMBL412927 | Forapin | Forapine |
| G-I-G-A-V-L-K-V-L-T-T-G-L-P-A-L-I-S-W-I-K-R-K-R-Q-Q-NH2 | GIGAVLKVLTTGLPALISWIKRKRQQ-NH2 | Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 |
| Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Gln-L-Gln-NH2 | H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 | Honeybee melittin |
| MFCD00076868 | Melittin | Melittin (GIGAVLKVLTTGLPALISWIKRKRQQ-amide) |
| Melittin (apis cerana) | Melittin (major) (8CI) | Melittin from honey bee venom, >=65% (HPLC) |
| Melittin from honey bee venom, >=85% (HPLC) | Melittin, >=97% (HPLC), synthetic | NCGC00167171-01 |
| RS-2008 | UNII-24VT8NVE75 | glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-glutamamide |
| CAS Number | 20449-79-0, 37231-28-0 |
| PubChem Compound | 16133648 |