Drug
D1326 | N-ethylmaleimide
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| TRANSPORT OF PHOSPHATE | 20 nmoles/mg protein | bovine | heart mitochondria and submitochondrial particles. | Determination of the energized accumulation of Pi and the binding of ADP; Assay of energized translocation of calcium and Pi | affect | 228 | ||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Phosphate carrier protein, mitochondrial | 20 nmoles/mg protein | bovine | heart mitochondria and submitochondrial particles. | Determination of the energized accumulation of Pi and the binding of ADP; Assay of energized translocation of calcium and Pi | inhibitor | 228 | ||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
Aggregated GHS information provided by 206 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H300 (99.03%): Fatal if swallowed [Danger Acute toxicity, oral] H301 (19.9%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (98.54%): Toxic in contact with skin [Danger Acute toxicity, dermal] H314 (99.51%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H317 (99.03%): May cause an allergic skin reaction [Warning Sensitization, Skin] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P261, P264, P270, P272, P280, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P333+P313, P361, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | behavioral: somnolence (general depressed activity) | National Technical Information Service. Vol. OTS0536969, |
| rat | LD50 | oral | 25mg/kg (25mg/kg) | National Technical Information Service. Vol. OTS0536969, | |
| mouse | LD50 | oral | 25mg/kg (25mg/kg) | behavioral: somnolence (general depressed activity) | National Technical Information Service. Vol. OTS0536969, |
| rat | LDLo | intracrebral | 1669ug/kg (1.669mg/kg) | Journal of Medicinal Chemistry. Vol. 15, Pg. 534, 1972. | |
| guinea pig | LD50 | skin | 500mg/kg (500mg/kg) | National Technical Information Service. Vol. OTS0536969, | |
| rat | LD50 | intraperitoneal | 1mg/kg (1mg/kg) | behavioral: somnolence (general depressed activity) | National Technical Information Service. Vol. OTS0536969, |
| 1-ETHYL-1H-PYRROLE-2,5-DIONENEM | 1-Ethyl-1H-Pyrrole-2, 5-dione | 1-Ethyl-1H-pyrrole-2,5-dione |
| 1-Ethyl-1H-pyrrole-2,5-dione # | 1-ethyl-2,5-dihydro-1H-pyrrole-2,5-dione | 1-ethyl-3-pyrroline-2,5-quinone |
| 1-ethylazoline-2,5-dione | 1-ethylpyrrole-2,5-dione | 128-53-0 |
| 1H-Pyrrole-2, 1-ethyl- | 1H-pyrrole-2,5-dione, 1-ethyl- | 25668-22-8 |
| 4D028806-9A8A-4D25-B355-AEFDEC5AD901 | 5-21-10-00006 (Beilstein Handbook Reference) | 7671AF |
| ACMC-209bf8 | AI3-50085 | AK-47781 |
| AKOS000249392 | AKOS025244114 | ANW-19074 |
| BDBM50220832 | BRD-K98297262-001-01-1 | BRN 0112448 |
| Bio1_000439 | Bio1_000928 | Bio1_001417 |
| C02441 | CCG-204583 | CHEBI:44485 |
| CHEMBL8211 | CS-0014814 | CTK1A6181 |
| DB-041899 | DB02967 | DTXSID1059573 |
| E 3876 | E-8100 | E0136 |
| EBD21453 | EINECS 204-892-4 | EU-0100492 |
| F0001-0396 | FS-4064 | FT-0631750 |
| GEO-01358 | GTPL5335 | HMS3261D05 |
| HSCI1_000382 | HY-D0843 | KBio2_002548 |
| KBio2_005116 | KBio2_007684 | KBio3_003026 |
| KBioGR_002548 | KBioSS_002557 | KS-00000GSO |
| LP00492 | LS-136944 | LS41520 |
| Lopac-E-3876 | Lopac0_000492 | MCULE-9216989340 |
| MFCD00005509 | Maleimide, N-ethyl- (8CI) | N-EM |
| N-Ethylmaleimide, 99+% | N-Ethylmaleimide, BioUltra, >=99.0% (HPLC) | N-Ethylmaleimide, BioXtra, >=98% (HPLC) |
| N-Ethylmaleimide, crystalline, >=98% (HPLC) | N-Ethylmaleimide, purum p.a., >=99.0% (HPLC) | N-ethylmaleimide |
| NCGC00015415-01 | NCGC00015415-02 | NCGC00015415-03 |
| NCGC00015415-04 | NCGC00093895-01 | NCGC00093895-02 |
| NCGC00261177-01 | NEM | NS00024051 |
| NSC 7638 | NSC-7638 | NSC-92547 |
| NSC7638 | NSC92547 | O3C74ACM9V |
| PI-149 | Q292393 | SCHEMBL19666 |
| SCHEMBL9359266 | SDCCGSBI-0050476.P003 | SR-01000075860 |
| SR-01000075860-1 | ST51037241 | STK802307 |
| Tox21_500492 | UNII-O3C74ACM9V | USAF B-121 |
| WLN: T5VNVJ B2 | ZINC901367 | cMAP_000078 |
| ethylmaleimide | maleic acid N-ethylimide | maleimide, N-ethyl- |
| n-ethylmaleimide (nem) | s3692 |