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Drug

D1331 | Tianeptine

Molecular Formula C21H25ClN2O4S
Molecular Weight 437
Structure
State solid
Clearance Rapidly cleared by the kidneys [L1429].
Volume of distribution 0.8 L/kg (0.77 +/- 0.31 L/kg) [A33320]
Route of elimination Eliminated with bile as glucuronide and glutamine conjugates [A32000].
Protein binding 95% bound to plasma protein [L1429].
Half life Approximately 2.5 h [A33320]
Absorption Well absorbed, approximately 99% bioavailability [A31998].
Description tricyclic antidepressant

N

N06AX14 Tianeptine


[N06AX] Other antidepressants


[N06A] ANTIDEPRESSANTS


[N06] PSYCHOANALEPTICS


[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTROPHORETIC UNCOUPLING 278
TCA 0.5 mM mouse The activity of the tricarboxylic acid cycle, assessed as the in vitro formation of [14C]CO2 from [1-14C]acetylcoenzyme A in vitro. affect 237
MITOCHONDRIAL FATTY ACID BETA OXIDATION 0.0625 mmol/kg i.p. mouse in vivo affect 237

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H362 (100%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]


H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P260, P263, P264, P270, P281, P308+P313, P314, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (+)-Tianeptine (-)-Tianeptine (1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide
    1159812-13-1 169293-31-6 191172-75-5
    23T172 66981-73-5 7-((3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoic acid
    7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid 7-[(6-chloro-10-methyl-9,9-dioxo-9$l^{6}-thia-10-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-yl)amino]heptanoic acid
    7-[[3-chloranyl-6-methyl-5,5-bis(oxidanylidene)-11H-benzo[c][2,1]benzothiazepin-11-yl]amino]heptanoic acid 72797-41-2 A835601
    AB0014029 AC-2091 AK323613
    AKOS015900590 AKU7QFL9ZT API0004407
    BCP10101 BRD-A53077924-236-01-4 C-22324
    CC-35054 CCG-269088 CHEBI:91749
    CHEMBL1289110 CS-0433 CT0196
    CTK7J3426 D02575 DB09289
    DTXSID7048295 EINECS 276-851-9 EX-A2724
    FT-0630770 FT-0675218 GTPL7558
    HY-90003 Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo(c,f)(1,2)thiazepin-11-yl)amino)-, (+)- Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo(c,f)(1,2)thiazepin-11-yl)amino)-, (-)-
    Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)-, S,S-dioxide, (+)- K099 KS-00000L5M
    KS-5099 MLS006010111 NS00008095
    NS00099110 Q-100759 Q424260
    S-16190 S-16191 SCHEMBL49293
    SMR004701247 Stablon (TN) Tianeptin
    Tianeptina Tianeptine Tianeptine (INN)
    Tianeptine Acid Tianeptine [INN] Tianeptine, (+)-
    Tianeptine, (-)- UNII-AKU7QFL9ZT UNII-XV6773012I
    W-5136 XV6773012I ZB1716
    s5087

    DrugBank DB09289
    CAS Number 1159812-13-1, 169293-31-6, 191172-75-5, 26638-66-4, 30123-17-2, 66981-73-5, 72797-41-2
    PubChem Compound 68870