MITOTOX

Compound

D1344 | erastin

Properties

Molecular Formula	C30H31ClN4O4
Molecular Weight	547
Structure
Description	oncogenic RAS-selective lethal small molecule; initiating ferroptotic cell death; binds and inhibits VDAC2 and VDAC3; inhibits the cystine-glutamate antiporter system Xc-

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
FERROPTOSIS	10μM					inducer		245

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Voltage-dependent anion-selective channel protein 2					VDAC2 binding assay			246

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

2-(1-(4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one	2-[1-[4-[2-(4-chlorophenoxy)-1-oxoethyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4-quinazolinone	2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one	2400AH	4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-
571203-78-6	AB0098412	AK473987
AKOS025147365	AOB6043	AS-55898
BCP27907	BDBM50376126	BRD-A25004090-001-01-9
BRD-A25004090-001-02-7	BRD-A25004090-001-06-8	C21478
CCG-269987	CHEBI:94287	CHEMBL401989
CS-1675	CTK1G7671	DA-42059
DTXSID80458949	ERASTIN	EX-A295
Erastin, >=98% (HPLC)	FT-0700333	HMS3653K21
HMS3868M03	HY-15763	KS-0000002U
MFCD09837984	NCGC00351608-10	NCGC00351608-14
Q27166099	QC-11375	SB19588
SCHEMBL4457820	SW208651-2	s7242

External IDs

CAS Number	571203-78-6
PubChem Compound	11214940