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2021 MitoTox | (CC BY-NC 4.0)
Drug

D1348 | Wortmannin

Molecular Formula C23H24O8
Molecular Weight 428.4
Structure
State solid
Description PI3K family inhibitor; suppress cellular autophagy and Akt phosphorylation; PI3K family inhibitor; suppress cellular autophagy and Akt phosphorylation; organic heteropentacyclic compound; a delta-lactone; an acetate ester; a cyclic ketone

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOPHAGY 100 nM SH-SY5Y neuroblastoma cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. 252

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]


H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]


H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P304+P340, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 intraperitoneal 18mg/kg (18mg/kg) "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 168, 1981.
rat LDLo oral 10mg/kg (10mg/kg) Experientia. Vol. 30, Pg. 135, 1974.


  • (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate (1R,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b- decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,
    (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
    (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione 19545-26-7 2-Oxaandrosta-5,5,4-bc]furan-3,7,17-trione, 11-(acetyloxy)-1-(methoxymethyl)-, (1.alpha.,11.alpha.)-
    2100AH 2803AH 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
    3H-Furo[4,2-de]indeno[4,5,-h]-2-benzopyran-3,6,9-trione, 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6br,9aS,11R,11bR) 3H-Furo[4,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6br,9aS,11R,11bR) 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-
    3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione,11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)- 3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1, 4-19-00-03134 (Beilstein Handbook Reference)
    44665-EP2277881A1 44665-EP2277898A2 44665-EP2292227A2
    44665-EP2301533A1 44665-EP2311818A1 6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-
    ACon0_000951 Antibiotic SL-2052 BDBM15234
    BIW4201 BRD-K87343924-001-02-4 BRN 0067676
    BS-16306 BSPBio_001232 C15181
    C23H24O8 CCG-208290 CHEBI:52289
    CHEMBL428496 CS-5073 CU-00000000011-1
    DB08059 DTXSID8040642 EX-A1930
    GTPL6060 HMS1792N13 HMS1990N13
    HMS3403N13 HY-10197 J-012661
    KS-00001CQL KY 12420 KY-12420
    KY-12420 KY12420 MEGxm0_000446
    MFCD00133927 MLS002703028 NCGC00163485-01
    NCGC00163485-02 NCI60_001835 NSC 627609
    NSC-221019 NSC-627609 NSC221019
    NSC627609 Pi 3-Kinase Inhibitor SCHEMBL4531
    SL-2052 SL-2052 SMR001566836
    ST-415 UNII-XVA4O219QW Wartmannin
    Wortmannin Wortmannin solution, 100 mug/mL in acetonitrile, analytical standard Wortmannin, 98%
    Wortmannin, Wm Wortmannin, from Penicillium funiculosum Wortmannin, from Penicillium funiculosum, >=98% (HPLC and TLC)
    Wortmannin,Penicillium wortmannin XVA4O219QW ZINC1619592
    ZX-AFC000406 cid_312145 nchembio866-comp1
    octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, [1S-(1alpha,6baalpha,9abeta,11alpha,11bbeta)]- s2758 wortmanin
    wortmannin

    DrugBank DB08059
    CAS Number 19545-26-7
    PubChem Compound 312145