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Drug

D1350 | AZD7545

Molecular Formula C19H18ClF3N2O5S
Molecular Weight 478.9
Structure
State solid
Trade names AZD7545 (AstraZeneca)
Description a novel, selective small-molecule inhibitor of PDHK2 (PDH kinase2) with an IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively

Target Dose Time Species Model Method Action Positive criterion Reference
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) IC50 255
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) 256


  • (R)-N-[2-Chloro-4-[[4-(dimethylcarbamoyl)phenyl]sulfonyl]phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide (R)-N-{2-Chloro-4-[4-(N,N-dimethylcarbamoyl)phenylsulphonyl]phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 2244AH
    252017-04-2 2q8g 4-[(3-Chloro-4-{[(2r)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropanoyl]amino}phenyl)sulfonyl]-N,N-Dimethylbenzamide
    4-[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]phenyl]sulfonyl-N,N-dimethylbenzamide 4-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethylbenzamide 4-{3-chloro-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamido]benzenesulfonyl}-N,N-dimethylbenzamide
    A14157 AK322219 AKOS027326647
    AOB6866 AS-75033 AZD 7545
    AZD 7545;AZD-7545 AZD-7545 AZD-7547
    AZD7545 AZX BCP07524
    BDBM50236535 BRD-K52836380-001-01-7 Benzamide, 4-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-
    C19H18ClF3N2O5S CCG-269530 CHEMBL1231132
    CS-1740 DB07403 EX-A1208
    GTPL9362 HY-16082 KS-00000RM2
    NCGC00250391-01 NCGC00250391-07 Q27096623
    SCHEMBL6350247 ZINC1547088 s7517

    DrugBank DB07403
    CAS Number 1816294-67-3, 252017-04-2
    PubChem Compound 16741245

    1. https://www.bocsci.com/tag/pyruvate-dehydrogenase-318.html