MITOTOX

Compound

D1351 | VER-246608

Properties

Molecular Formula	C28H23ClF2N4O4
Molecular Weight	553
Structure
Description	a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively

Therapeutic Classification Source: DrugBank

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)								256

Indications Source: SIDER

Synonyms Source: PubChem

1684386-71-7	4v25	BCP29722
BDBM50236530	CHEMBL3727577	CS-0011787
EX-A3785	GTPL9350	HY-12492
N-(4-(2-chloro-5-methylpyrimidin-4-yl)phenyl)-N-(4-((2,2-difluoroacetamido)methyl)benzyl)-2,4-dihydroxybenzamide	N-[4-(2-Chloro-5-Methylpyrimidin-4-Yl)phenyl]-N-(4-{[(Difluoroacetyl)amino]methyl}benzyl)-2,4-Dihydroxybenzamide	N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-N-[[4-[[(2,2-difluoroacetyl)amino]methyl]phenyl]methyl]-2,4-dihydroxybenzamide
Q27465596	SCHEMBL16586236	SZ6
VER 246608	VER-246608	VER246608

External IDs

CAS Number	1684386-71-7
PubChem Compound	86280454

References

1. https://www.bocsci.com/tag/pyruvate-dehydrogenase-318.html