D1354 | AICAR
C
C01EB13 Acadesine
[C01EB] Other cardiac preparations
[C01E] OTHER CARDIAC PREPARATIONS
[C01] CARDIAC THERAPY
[C] Cardiovascular system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MITOCHONDRIAL FATTY ACID BETA OXIDATION | 1mM | 24hr | U-937, MCF-7, and T47D | quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion | stimulate | 273 | ||
| MITOCHONDRIAL FATTY ACID BETA OXIDATION | stimulate | 273 | ||||||
| SIGNALING | 248 | |||||||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetyl-CoA carboxylase 2 | 1mM | 24hr | U-937, MCF-7, and T47D | quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion | inactivation | 273 | ||
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | 248 | |||||||
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | activation | 273 | ||||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 44 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 2 of 44 companies. For more detailed information, please visit ECHA C&L website Of the 5 notification(s) provided by 42 of 44 companies with hazard statement code(s): H315 (97.62%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (97.62%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (95.24%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| 1H-Imidazole-4-carboxamide, 5-amino-1-beta-D-ribofuranosyl- | 2627-69-2 | 5-Amino-1-.beta.-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| 5-Amino-1-.beta.-D-ribofuranosylimidazole-4-carboxamide | 5-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-imidazole-4-carboxamide | 5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| 5-Amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide | 5-Amino-1-beta-D-ribofuranosylimidazole-4-carboxamide | 5-Amino-1-beta-ribofuranosyl-imidazole-4-carboxamide |
| 5-Amino-1-beta-ribofuranosylimidazole-4-carboxamide | 5-Amino-1beta-D-ribofuranosylimidazole-4-carboxyamide | 5-Amino-4-imidazolecarboxamide Riboside |
| 5-Amino-4-imidazolecarboxamide ribofuranoside | 5-Aminoimidazole-4-carboxamide ribonucleoside | 5-Aminoimidazole-4-carboxamide riboside |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, 98% | 5-Aminoimidazole-4-carboxamide-1-beta-riboside | 5-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-imidazole-4-carboxamide |
| 5-amino-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide | 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]imidazole-4-carboxamide | 5-amino-1-ribofuranosylimidazole-4-carboxamide |
| 5-amino-1-ss-D-ribofuranosyl-1H-imidazole-4-carboxamide | 5-amino-1-ss-D-ribofuranosyl-1H-imidazole-4-carboxamide;5-amino-1-?-D-ribofuranosyl-1H-imidazole-4-carboxamide | 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside |
| 53IEF47846 | 627A692 | AC-26840 |
| ACADESINE | AIC-Riboside | AICA riboside |
| AICA-riboside | AICAR | AICAR (Acadesine) |
| AICAR, >=98% (HPLC), powder | AICAR;5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside | AK-28518 |
| AKOS016004462 | AMTNS043 | AOB3884 |
| API0015387 | AS-13787 | ATH-001 |
| AX8007017 | Acadesina | Acadesina [INN-Spanish] |
| Acadesine (AIACR) | Acadesine (USAN/INN) | Acadesine [USAN:INN:BAN] |
| Acadesinum | Acadesinum [INN-Latin] | Acadra |
| Arasine | C04663 | C9H14N4O5 |
| CAS-2627-69-2 | CCG-267038 | CHEBI:28498 |
| CHEMBL1551724 | CS-1951 | D02742 |
| DB04944 | DSSTox_CID_26015 | DSSTox_GSID_46015 |
| DSSTox_RID_81290 | DTXSID5046015 | EC Number 220-097-5 |
| EINECS 220-097-5 | GP 1-110 | GP-1-110 |
| GP-1-110-0 | GTPL5133 | HSCI1_000213 |
| HY-13417 | Imidazole-4-carboxamide, 5-amino-1-beta-D-ribofuranosyl- | J-700140 |
| J10316 | LS00141 | MFCD00869751 |
| MLS004774120 | MLS006010069 | N(1)-(beta-D-ribofuranosyl)-5-aminoimidazole-4-carboxamide |
| N1-(?-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide | N1-(beta-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide | NCGC00096051-02 |
| NCGC00165736-01 | NCGC00165736-03 | NCGC00165736-04 |
| NSC 105823 | NSC-105823 | NSC105823 |
| OR1170T | Protara | Q4671562 |
| SB16556 | SC-19362 | SCH-900395 |
| SCHEMBL219336 | SMR003435998 | SRI-4077-02 |
| SRI-4077_04 | Tox21_111551 | Tox21_111551_1 |
| UNII-53IEF47846 | Z-Riboside | ZINC3798074 |
| ZX-AT019278 | ath001 | s1802 |