Drug
D1356 | Dichloroacetate
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| GLYCOLYSIS | inhibition | 278 | ||||||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Glyceraldehyde-3-phosphate dehydrogenase | inhibit | 278 | ||||||
| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII) | IC50 | 255 | ||||||
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 50mg/kg/16W-I (50mg/kg) | New England Journal of Medicine. Vol. 300, Pg. 372, 1979. | |
| 13425-80-4 | 2,2-bis(chloranyl)ethanoate | 2,2-dichloroacetate |
| 2q8h | 68626-EP2292227A2 | 68626-EP2292628A2 |
| 68626-EP2298776A1 | 68626-EP2308861A1 | 68626-EP2374454A1 |
| A839686 | ACETIC ACID, DICHLORO-, ION(1-) | Acetic acid,2,2-dichloro-, ion(1-) |
| BRN 3903873 | CHEBI:28240 | CTK4B9070 |
| DCA | DTXSID40158610 | Dichloracetate |
| Dichloroacetate | Dichloroacetate ion | Dichloroacetic acid ion(1-) |
| GTPL4518 | LS-11597 | NCGC00241105-01 |
| Q27077050 | STL483470 |