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Drug

D1366 | hydroxychloroquine

Molecular Formula C18H26ClN3O
Molecular Weight 335.9
Structure
State solid
Protein binding Approximately 45%.
Half life Terminal elimination half-life In blood is approximately 50 days. In plasma it is approximately 32 days.
Absorption Very rapidly and completely absorbed following oral administration.
Trade names Plaquenil
Description antimalarial; 4-aminoquinoline families ; lysosomal inhibitor; medication used to prevent and treat malaria

P

P01BA02 Hydroxychloroquine


[P01BA] Aminoquinolines


[P01B] ANTIMALARIALS


[P01] ANTIPROTOZOALS


[P] Antiparasitic products, insecticides and repellents

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOPHAGY 30 μM SH-SY5Y neuroblastoma cells Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye. 252

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
child LDLo oral 600mg/kg (600mg/kg) Journal of Analytical Toxicology. Vol. 14, Pg. 186, 1990.
women TDLo oral 400mg/kg (400mg/kg) Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 861, 1999.


  • (+-)-hydroxychloroquine (+/-)-hydroxychloroquine (.+/-.)-Hydroxychloroquine
    118-42-3 118H423 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol
    2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol 2-((4-(7-chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol 2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol
    2-({4-[(7-chloro(4-quinolyl))amino]pentyl}ethylamino)ethan-1-ol 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol 2-[(4-[(7-Chloro-4-quinolinyl)amino]pentyl)(ethyl)amino]ethanol #
    2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol 2-[[4-[(7-chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol
    2-[{4-[(7-Chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethan-1-ol 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol 2-{N-[4-(7-Chloro-4-quinolylamino)pentyl]-N-ethylamino}ethanol
    5-22-10-00280 (Beilstein Handbook Reference) 7-Chloro-4-(4-(N-ethyl-N-.beta.-hydroxyethylamino)-1-methylbutylamino)quinoline 7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
    7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline 7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline 7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline
    7-chloro-4-[4-[ethyl(2-hydroxyethyl)amino]1-methylbutylamino]-quinoline 7-chloro-4-[4-[ethyl(2-hydroxyethyl)amino]1-methylbutylamino]quinoline 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline
    AB00053257_02 AKOS015997886 ALBB-022466
    BCP30197 BDBM50467780 BRD-A99117172-065-01-6
    BRD-A99117172-065-02-4 BRN 0253894 C07043
    C18H26ClN3O CC-29437 CCG-208059
    CHEBI:5801 CHEMBL1535 CS-0075751
    Chloroquine-Hydroxy D08050 DB01611
    DT-0016 DTXSID8023135 DivK1c_000942
    Dolquine EINECS 204-249-8 Ercoquin (Salt/Mix)
    Ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)- Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)- Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-
    Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1) Ethanol, 2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]ethylamino]- F2173-0553
    FT-0627143 FT-0669455 FT-0669456
    GTPL7198 HCQ HMS502P04
    HY-W031727 HYDROXY CHLOROQUINE Hidroxicloroquina
    Hidroxicloroquina [INN-Spanish] Hydroxiklorokin Hydroxychlorochin
    Hydroxychloroquine (INN) Hydroxychloroquine Sulfate (1:1) Salt Hydroxychloroquine [INN:BAN]
    Hydroxychloroquine sulphate;hydroxychloroquine sulphate;Hydroxychloroquine sulfate Hydroxychloroquinum Hydroxychloroquinum [INN-Latin]
    IDI1_000942 Idrossiclorochina Idrossiclorochina [DCIT]
    KBio1_000942 LS-66614 M566
    MCULE-6282304706 NCGC00159483-02 NCGC00159483-03
    NCGC00159483-06 NINDS_000942 NS00001228
    NS00098843 NSC4375 Oxichlorochinum
    Oxichloroquine Oxichloroquine;Oxychlorochin;2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol Oxychlorochin
    Oxychloroquine Plaquenil Polirreumin
    Polirreumin (TN) Q421094 Quensyl
    SBB012559 SBI-0052759.P002 SCHEMBL8170
    SPBio_001116 ST072188 STL429829
    Spectrum2_001238 Spectrum5_001697 VZ36170
    WIN 1258 Win 1258-2 ZX-AN038051
    hydroxychloroquine oxichlorochine

    DrugBank DB01611
    CAS Number 118-42-3, 158749-76-9, 747-36-4
    PubChem Compound 3652