MITOTOX

Compound

D1378 | 3-Bromopyruvate

Properties

Molecular Formula	C3H3BrO3
Molecular Weight	166.96
Structure
Description	a 2-oxo monocarboxylic; synthetic brominated derivative and structural analog of pyruvic acid; Highly reactive alkylating agent; Anti-cancer drug

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
GLYCOLYSIS								249
GLUCOSE GALACTOSE IC50 RATIO	1			LUHMES (Lund human mesencephalic) cells	Glc–Gal–NeuriTox assay	Negative	EC25(NA) [Glc/Gal]	326

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Hexokinase-1								249

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 47 companies from 5 notifications to the ECHA C&L Inventory. H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 47 companies from 5 notifications to the ECHA C&L Inventory.

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Acute Effects Source: ChemIDplus

Organism	Test type	Route	Dose (normalized dose)	Effect	Source
mouse	LD50	intraperitoneal	72mg/kg (72mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 48, 1958.

Indications Source: SIDER

Synonyms Source: PubChem

.beta.-Bromopyruvic acid	1113-59-3	3-BP
3-Bromo-2-oxopropanoic acid #	3-Bromo-2-oxopropionic acid	3-Bromopyruvic acid hydrate,98
3-bromo-2-keto-propionic acid	3-bromo-2-oxo-propionic acid	3-bromo-2-oxopropanoic acid
3-bromo-2-oxopropanoic acid	3-bromopyruvate	3-bromopyruvic acid
63JMV04GRK	A-2150	ACMC-1C0WT
ACT09279	AK00558616	AKOS015892643
AM84337	ANW-43645	AS-16146
B1153	BPV	BRD-K92980438-001-01-7
BRN 1746786	Bromopyruvic acid	Bromopyruvic acid, >=97.0% (T)
Bromopyruvicacid	C3H3BrO3	CCG-266336
CHEBI:131461	CHEBI:95046	CHEMBL177837
CS-5517	CTK3J2529	DA-15474
DTXSID7040940	EINECS 214-206-5	EN300-67360
FT-0623262	HMS3741K19	HMS3866H13
HY-19992	Hexokinase II Inhibitor II;3-BP	J-511892
J-650255	KS-00000WGC	KSC492K2T
LS-139787	MCULE-4768170572	MFCD00002587
NCIOpen2_000241	NS00023565	NSC 11731
NSC 62343	NSC-11731	NSC-62343
NSC11731	NSC62343	Propanoic acid, 3-bromo-2-oxo-
Pyruvic acid, bromo-	Q3608257	S691
SBB053571	SC-15238	SCHEMBL8126
ST51037166	UNII-63JMV04GRK	Z2690354216
ZINC1718542	bromo-2-oxopropanoic acid	bromopyruvate
bromopyruvic acid	s5426

External IDs

CAS Number	1113-59-3, 206860-50-6
PubChem Compound	70684