MITOTOX

Drug

D1395 | piceatannol

Properties

Molecular Formula	C14H12O4
Molecular Weight	244.24
Structure
State	solid
Description	glucoside, astringin, are phenolic compounds; an analog of resveratrol; metabolite of resveratrol found in red wine, grapes etc.

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
FISSION		48hr		Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct	Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter			276

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Mitofusin-1		48hr		Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct	Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter	down regulate		276

Acute Effects Source: ChemIDplus

Organism	Test type	Route	Dose (normalized dose)	Effect	Source
mouse	LD50	intraperitoneal	217mg/kg (217mg/kg)	behavioral: somnolence (general depressed activity)	Chemical and Pharmaceutical Bulletin. Vol. 32, Pg. 213, 1984.

Indications Source: SIDER

External IDs

DrugBank	DB08399
CAS Number	10083-24-6, 1012-91-5, 4339-71-3
PubChem Compound	667639

References