MITOTOX

Drug

D1399 | Terbinafine

Properties

Molecular Formula	C21H25N
Molecular Weight	291.4
Structure
State	solid
Route of elimination	Prior to excretion, terbinafine is extensively metabolized.
Protein binding	>99%
Half life	36 hours
Absorption	Readily absorbed from gastrointestinal tract.
Trade names	Lamisil
Description	antifungal

Therapeutic Classification Source: DrugBank

D01BA02 Terbinafine

[D01BA] Antifungals for systemic use

[D01B] ANTIFUNGALS FOR SYSTEMIC USE

[D01] ANTIFUNGALS FOR DERMATOLOGICAL USE

[D] Dermatological drugs

D01AE15 Terbinafine

[D01AE] Other antifungals for topical use

[D01A] ANTIFUNGALS FOR TOPICAL USE

[D01] ANTIFUNGALS FOR DERMATOLOGICAL USE

[D] Dermatological drugs

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Method	Action	Reference
LIPID PEROXIDATION	4mg/ml		Aspergillus fumigatus	lipid peroxidation using the thiobarbituric acid assay	induce	304
LIPID PEROXIDATION	4mg/ml	3min, 5min, 15min	Aspergillus fumigatus	mitochondrion-specific lipid peroxidation probe MitoPerOx	induce	304
ROS PRODUCTION	4mg/ml		Aspergillus fumigatus	oxidant-sensing fluorescent probe 2′,7′-dichlorofluorescin diacetate t	induce	304

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Mitofusin-1		48hr		Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct	Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter	up regulate		276

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Warning	Aggregated GHS information provided by 157 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Warning

Aggregated GHS information provided by 157 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

External IDs

DrugBank	DB00857
CAS Number	35115-60-7, 78628-80-5, 91161-71-6
PubChem Compound	1549008