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Drug

D1400 | Chloroquine

Molecular Formula C18H26ClN3
Molecular Weight 319.9
Structure
State solid
Route of elimination Excretion of chloroquine is quite slow, but is increased by acidification of the urine.
Protein binding ~55% of the drug in the plasma is bound to nondiffusible plasma constituents
Half life 1-2 months
Absorption Completely absorbed from gastrointestinal tract
Description prevent and treat malaria; drug class 4-aminoquinoline

P

P01BA01 Chloroquine


[P01BA] Aminoquinolines


[P01B] ANTIMALARIALS


[P01] ANTIPROTOZOALS


[P] Antiparasitic products, insecticides and repellents

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTROPHORETIC UNCOUPLING 278
AUTOPHAGY 1µM overnight HeLa cells Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay induce >2 fold increase 277

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 intravenous 60mg/kg (60mg/kg) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 38, 1966.
mouse LD50 oral 311mg/kg (311mg/kg) Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 753, 1973.
women LDLo oral 180mg/kg (180mg/kg) Medical Journal of Australia. Vol. 160, Pg. 231, 1994.
child LDLo oral 37593ug/kg (37.593mg/kg) Annals of Emergency Medicine. Vol. 19, Pg. 47, 1990.
rabbit LDLo intramuscular 20mg/kg (20mg/kg) Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 15, Pg. 630, 1980.
rat LD50 oral 330mg/kg (330mg/kg) Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 271, 1983.
mouse LD50 intraperitoneal 66mg/kg (66mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1219, 1982.
rat LD50 intraperitoneal 102mg/kg (102mg/kg) gastrointestinal: other changes Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 401, 1975.
rabbit LD50 intravenous 8mg/kg (8mg/kg) Therapie. Vol. 25, Pg. 823, 1970.
mouse LD50 subcutaneous 150mg/kg (150mg/kg) Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
women LDLo oral 110mg/kg (110mg/kg) New England Journal of Medicine. Vol. 318, Pg. 1, 1988.
women TDLo oral 24mg/kg/12D-I (24mg/kg) Annals of Internal Medicine. Vol. 123, Pg. 76, 1995.
man LDLo oral 86mg/kg (86mg/kg) New England Journal of Medicine. Vol. 318, Pg. 1, 1988.
human LDLo oral 20mg/kg (20mg/kg) Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
mouse LD50 intramuscular 71mg/kg (71mg/kg) Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 4, Pg. 69, 1983.
rabbit LD50 subcutaneous 75mg/kg (75mg/kg) Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
rat LD50 subcutaneous 190mg/kg (190mg/kg) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 38, 1966.
women TDLo oral 3600mg/kg/3Y (3600mg/kg) Tropical and Geographical Medicine. Vol. 32, Pg. 216, 1980.
mouse LD50 intravenous 21600ug/kg (21.6mg/kg) Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 4, Pg. 69, 1983.


  • DrugBank DB00608
    CAS Number 117399-83-4, 132-73-0, 50-63-5, 54-05-7, 56598-66-4, 58175-86-3, 58175-87-4
    PubChem Compound 2719