D1401 | Brefeldin A
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| GLUCOSE GALACTOSE IC50 RATIO | 0.7 | LUHMES (Lund human mesencephalic) cells | Glc–Gal–NeuriTox assay | Negative | EC25(NA) [Glc/Gal] | 326 | ||
| AUTOPHAGY | 1µM | overnight | HeLa cells | Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay | induce | >2 fold increase | 277 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. H301 (95.24%): Toxic if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 154 companies from 1 notifications to the ECHA C&L Inventory. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | Japanese Journal of Antibiotics. Vol. 34, Pg. 51, 1981. | |