MITOTOX

Compound

D1402 | Tunicamycin

Properties

Molecular Formula	C30H46N4O16
Molecular Weight	718.7
Structure
State	solid
Description	mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc; causes cell cycle arrest in G1 phase; induce unfolded protein response

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
AUTOPHAGY	1µM	overnight		HeLa cells	Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay	induce	>2 fold increase	277

Acute Effects Source: ChemIDplus

Organism	Test type	Route	Dose (normalized dose)	Effect	Source
rat	LD	subcutaneous	> 200ug/kg (0.2mg/kg)		Australian Veterinary Journal. Vol. 76, Pg. 287, 1998.
domestic animals - goat/sheep	LDLo	subcutaneous	20ug/kg (0.02mg/kg)		Australian Veterinary Journal. Vol. 76, Pg. 287, 1998.
rat	LD	subcutaneous	> 200ug/kg (0.2mg/kg)	liver: other changes	Australian Veterinary Journal. Vol. 76, Pg. 287, 1998.
guinea pig	LD	subcutaneous	> 400ug/kg (0.4mg/kg)		Pathology. Vol. 21, Pg. 194, 1989.

Indications Source: SIDER

External IDs

DrugBank	DB13172
CAS Number	11089-65-9
PubChem Compound	6433557

References