MITOTOX

Drug

D1404 | Staurosporine

Properties

Molecular Formula	C28H26N4O3
Molecular Weight	466.5
Structure
State	solid
Description	microbial alkaloids with bis-indole chemical structure; inhibition of protein kinases through the prevention of ATP binding to the kinase; potent, non-selective inhibitor of protein kinases, including protein kinase C; anti-fungal; anti-hypertensive

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ROS PRODUCTION	2 µM	24hr		U2OS	mt-roGFP and mitoSOX	increase		313
AUTOPHAGY	1µM	overnight		HeLa cells	Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay	induce	>2 fold increase	277

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 6 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H228 (16.67%): Flammable solid [Danger Flammable solids] H300 (16.67%): Fatal if swallowed [Danger Acute toxicity, oral] H302 (16.67%): Harmful if swallowed [Warning Acute toxicity, oral] H310 (16.67%): Fatal in contact with skin [Danger Acute toxicity, dermal] H340 (33.33%): May cause genetic defects [Danger Germ cell mutagenicity] H350 (50%): May cause cancer [Danger Carcinogenicity] H351 (16.67%): Suspected of causing cancer [Warning Carcinogenicity] H361 (16.67%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H373 (16.67%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400 (16.67%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (33.33%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P201, P202, P210, P240, P241, P260, P262, P264, P270, P273, P280, P281, P301+P310, P301+P312, P302+P350, P308+P313, P310, P314, P321, P322, P330, P361, P363, P370+P378, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 6 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H228 (16.67%): Flammable solid [Danger Flammable solids]

H300 (16.67%): Fatal if swallowed [Danger Acute toxicity, oral]

H302 (16.67%): Harmful if swallowed [Warning Acute toxicity, oral]

H310 (16.67%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H340 (33.33%): May cause genetic defects [Danger Germ cell mutagenicity]

H350 (50%): May cause cancer [Danger Carcinogenicity]

H351 (16.67%): Suspected of causing cancer [Warning Carcinogenicity]

H361 (16.67%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H373 (16.67%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (16.67%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (33.33%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P201, P202, P210, P240, P241, P260, P262, P264, P270, P273, P280, P281, P301+P310, P301+P312, P302+P350, P308+P313, P310, P314, P321, P322, P330, P361, P363, P370+P378, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

antibiotic AM-2282 or STS

External IDs

DrugBank	DB02010
CAS Number	109189-95-9, 62996-74-1
PubChem Compound	44259