MITOTOX

Compound

D1405 | alpha-Cyano-4-hydroxycinnamate

Properties

Molecular Formula	C10H7NO3
Molecular Weight	189.17
Structure
Description	cinnamic acid derivative; phenylpropanoid

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
TRANSPORT OF PYRUVATE	1mM	3min	rat	inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria	The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient.	inhibitor		279
TRANSPORT OF PYRUVATE	0.05mM					inhibitor	>90% inhibition	280

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Pyruvate carboxylase, mitochondrial	2mM			fat cell		inhibit	25% inhibition	280
NADP-dependent malic enzyme, mitochondrial	0.05mM			fat cell		inhibit	15% inhibition	280

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Warning	Aggregated GHS information provided by 162 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H315 (99.38%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (99.38%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (98.77%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Warning

Aggregated GHS information provided by 162 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H315 (99.38%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (99.38%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (98.77%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

External IDs

CAS Number	122520-77-8, 28166-41-8, 29103-58-0
PubChem Compound	5328791