D1405 | alpha-Cyano-4-hydroxycinnamate

Molecular Formula C10H7NO3
Molecular Weight 189.17
Description cinnamic acid derivative; phenylpropanoid

Toxicity Dose Time Species Model Method Action Positive criterion Reference
TRANSPORT OF PYRUVATE 1mM 3min rat inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient. inhibitor 279
TRANSPORT OF PYRUVATE 0.05mM inhibitor >90% inhibition 280

Target Dose Time Species Model Method Action Positive criterion Reference
Pyruvate carboxylase, mitochondrial 2mM fat cell inhibit 25% inhibition 280
NADP-dependent malic enzyme, mitochondrial 0.05mM fat cell inhibit 15% inhibition 280

Pictogram Signal Statements Precautionary Statement Codes

Aggregated GHS information provided by 162 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H315 (99.38%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (99.38%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (98.77%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure

Respiratory tract irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • CAS Number 122520-77-8, 28166-41-8, 29103-58-0
    PubChem Compound 5328791