Drug

D1407 | Carnitine

Molecular Formula C7H15NO3
Molecular Weight 161.2
Structure
State solid
Clearance Total body clearance was found to be a mean of 4L/h.
Volume of distribution The steady state volume of distribution (Vss) of an intravenously administered dose, above endogenous baseline levels, was calculated to be 29.0 +/- 7.1L. However this value is predicted to be an underestimate of the true Vss.
Route of elimination Following a single intravenous dose, 73.1 +/- 16% of the dose was excreted in the urine during the 0-24 hour interval. Post administration of oral carnitine supplements, in addition to a high carnitine diet, 58-65% of the administered radioactive dose was recovered from urine and feces in 5-11 days.
Protein binding None
Half life 17.4 hours (elimination) following a single intravenous dose.
Absorption Absolute bioavailability is 15% (tablets or solution). Time to maximum plasma concentration was found to be 3.3 hours.
Description quaternary ammonium compound involved in metabolism

A

A16AA01 Levocarnitine


[A16AA] Amino acids and derivatives


[A16A] OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS


[A16] OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS


[A] Alimentary tract and metabolism


Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIAL FATTY ACID BETA OXIDATION 0.5mM 24hr U-937, MCF-7, and T47D quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion stimulate 273

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 subcutaneous 13500mg/kg (13500mg/kg) Acta Biologica et Medica Germanica. Vol. 3, Pg. 28, 1959.
mouse LD50 intravenous 610mg/kg (610mg/kg) British UK Patent Application. Vol. #2008578,
rat LD50 intravenous 995mg/kg (995mg/kg) British UK Patent Application. Vol. #2008578,
mouse LD50 subcutaneous 11500mg/kg (11500mg/kg) Acta Biologica et Medica Germanica. Vol. 3, Pg. 28, 1959.


  • beta-hydroxy-gamma-N-trimethylaminobutyric acid, 3-hydroxy-4-N,N,N-trimethylaminobutyrate

    DrugBank DB00583
    CAS Number 406-76-8, 461-05-2, 461-06-3, 496-93-5, 541-14-0, 541-15-1
    PubChem Compound 288