MITOTOX

Drug

D1415 | Xanthohumol

Molecular Formula	C21H22O5
Molecular Weight	354.4
Structure
Description	a PHB2(Prohibitin-2) ligand ; prenylated chalconoid; natural product found in the female inflorescences of Humulus lupulus( hops)

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
MITOPHAGY	30μM	24hr		MCF7 cells	using the MAP1LC3II/I ratio to monitor the autophagic flux; quantifiedPMPCB staining	block		283

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Prohibitin-2	30μM	24hr		MCF7 cells	using the MAP1LC3II/I ratio to monitor the autophagic flux; quantifiedPMPCB staining	ligand		283