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Compound

D1432 | MCU-i4

Molecular Formula C23H27N3O2
Molecular Weight 377.5
Structure
Description Novel negative modulator of the MCU, binding MICU1

Toxicity Dose Time Species Model Method Action Positive criterion Reference
TRANSMEMBRANE POTENTIAL 10 μM 15min HeLa cells TMRM (using the Mitochondrial Membrane Potential Indicator Kit) Negative 301
TRANSPORT OF CALCIUM 5 μM HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine Highigh-throughput screening assay based on aequorin. decrease 301
TRANSPORT OF CALCIUM 10 μM mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines Small-Scale Validation Assay (cytoplasmic- or mitochondria-targeted aequorin (cytAeq and mtAeq, respectively) decrease 301
TRANSPORT OF CALCIUM 8.4 μM(Micu1), 18 μM (Micu1-Micu2) Purified recombinant Micu1, Micu2 Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface. decrease IC50 301
TRANSPORT OF CALCIUM 10 μM Skeletal Muscle Fibers measured mitochondrial Ca2+ uptake in flexor digitorum brevis (FDB) myofibers freshly isolated from adult mice and previously transfected in vivo with the mitochondria-targeted Ca2+ probe 4mt-GCaMP6f decrease 301

Target Dose Time Species Model Method Action Positive criterion Reference
Calcium uptake protein 1, mitochondrial 5 μM HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine Highigh-throughput screening assay based on aequorin. inhibit 301
Calcium uptake protein 1, mitochondrial 8.4 μM(Micu1), 18 μM (Micu1-Micu2) Purified recombinant Micu1, Micu2 Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface. inhibit IC50 301


  • 3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate

    CAS Number 371924-24-2
    PubChem Compound 1568449