Compound
D1433 | MCU-i11
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| TRANSMEMBRANE POTENTIAL | 10 μM | 15min | HeLa cells | TMRM (using the Mitochondrial Membrane Potential Indicator Kit) | Negative | 301 | ||
| TRANSPORT OF CALCIUM | 5 μM | HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine | Highigh-throughput screening assay based on aequorin. | decrease | 301 | |||
| TRANSPORT OF CALCIUM | 10 μM | mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines | Small-Scale Validation Assay (cytoplasmic- or mitochondria-targeted aequorin (cytAeq and mtAeq, respectively) | decrease | 301 | |||
| TRANSPORT OF CALCIUM | 2.9 μM(Micu1), 2.7 μM (Micu1-Micu2) | Purified recombinant Micu1, Micu2 | Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface. | decrease | IC50 | 301 | ||
| TRANSPORT OF CALCIUM | 10 μM | Skeletal Muscle Fibers | measured mitochondrial Ca2+ uptake in flexor digitorum brevis (FDB) myofibers freshly isolated from adult mice and previously transfected in vivo with the mitochondria-targeted Ca2+ probe 4mt-GCaMP6f | decrease | 301 | |||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Calcium uptake protein 1, mitochondrial | 5 μM | HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine | Highigh-throughput screening assay based on aequorin. | inhibit | 301 | |||
| Calcium uptake protein 1, mitochondrial | 2.9 μM(Micu1), 2.7 μM (Micu1-Micu2) | Purified recombinant Micu1, Micu2 | Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface. | inhibit | IC50 | 301 | ||
| 2-(7-Acetyl-3-benzyl-2,4-dioxo-3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-1(2H)-yl)-N-(4-ethoxyphenyl)acetamide | Pyrido[4’,3′:4,5]thieno[2,3-d]pyrimidine-1(2H)-acetamide, 7-acetyl-N-(4-ethoxyphenyl)-3,4,5,6,7,8-hexahydro-2,4-dioxo-3-(phenylmethyl)- |
| CAS Number | 902903-59-7 |
| PubChem Compound | 16010455 |