MITOTOX

Compound

D1435 | DS16570511

Properties

Molecular Formula	C30H25Cl2N3O4
Molecular Weight	562.4
Structure
Description	inhibitor of the mitochondrial calcium uniporter; It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively).

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
TRANSPORT OF CALCIUM	7 μM			HEK293A cells	HEK293A cell lines expressing the mitochondria-targeted Ca2+ indicator protein aequorin	decrease	IC50	302

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
mCU (mitochondrial calcium uniporter)	7 μM			HEK293A cells	HEK293A cell lines expressing the mitochondria-targeted Ca2+ indicator protein aequorin	inhibit	IC50	302

Indications Source: SIDER

Synonyms Source: PubChem

3-[3-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl]amino]benzoyl]-1H-indole-1-butanoic acid

External IDs

CAS Number	2446154-84-1
PubChem Compound	137700533

References