MITOTOX

Drug

D1448 | camptothecin

Structure
Description	topoisomerase poison; alkaloid; pyranoindolizinoquinoline; during the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks.

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ROS PRODUCTION	30 µM	24hr		U2OS	mt-roGFP and mitoSOX	increase		313
ROS PRODUCTION	30 µM	24hr		U2OS	U2OS cells stably expressing mt-roGFP and HyPer-red targeted at mitochondria	increase		313