Drug

D1448 | camptothecin

Structure
Description topoisomerase poison; alkaloid; pyranoindolizinoquinoline; during the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks.

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ROS PRODUCTION 30 µM 24hr U2OS mt-roGFP and mitoSOX increase 313
ROS PRODUCTION 30 µM 24hr U2OS U2OS cells stably expressing mt-roGFP and HyPer-red targeted at mitochondria increase 313


  • DrugBank DB04690
    CAS Number 7689-03-04 00:00:00
    PubChem Compound 24360