Drug
D1449 | neomycin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| ACCUMULATION OF CALCIUM | 400 μM | zebrafish | zebrafish lateral line hair | measrueing cytoplasmic oxidation (HyPer) and mitochondrial Ca2+ uptake (mitoRGECO) | increase | 315 | ||
| ROS PRODUCTION | 50 μM | zebrafish | zebrafish lateral line hair | use ROS indicator dye cellROX green ( it labels a number of intracellular compartments, including cytoplasm, nucleus, and mitochondria) | increase | 315 | ||