D1480 | palmitoylaminocarnitine

Description long-chain acyl derivatives of aminocarnitine

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIAL FATTY ACID BETA OXIDATION 2.8/0.27 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition IC50 (μM) 333
SYNTHESIS OF KETONE BODY 0.11 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition IC50 (μM) 333

Target Dose Time Species Model Method Action Positive criterion Reference
Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, EC 2.3.1.21 2.67/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB inhibition IC50 (μM) 333
Carnitine O-palmitoyltransferase 1, muscle isoform 21.7 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB inhibition IC50 (μM) 333
Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21 0.14 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB inhibition IC50 (μM) 333