D1481 | ST1326

Description Carnitine Derivative; aliphatic carbon chain and is structurally similar to palmitoylcarnitine

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIAL FATTY ACID BETA OXIDATION 4.0/0.98 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition IC50 (μM) 333
SYNTHESIS OF KETONE BODY 1.1 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition IC50 (μM) 333

Target Dose Time Species Model Method Action Positive criterion Reference
Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, EC 2.3.1.21 1.05/1.45 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB inhibition IC50 (μM) 333
Carnitine O-palmitoyltransferase 1, muscle isoform 5.4 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB inhibition IC50 (μM) 333
Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21 0.16/0.38 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB inhibition IC50 (μM) 333


  • (R)-3-(3-tetradecylureido)-4-(trimethylammonio)butanoate

    CAS Number 250694-07-6