D1485 | TDGA

Description oxirane carboxylate inhibitor of mitochondrial carnitine plamitoyltransferase-1,

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIAL FATTY ACID BETA OXIDATION <0.05/0.04 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition IC50 (μM) 333
SYNTHESIS OF KETONE BODY 0.31 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition IC50 (μM) 333

  • 2-tetradecylglycidic acid McN-3802 Palmoxiric acid

    PubChem Compound 71976