D1487 | DET

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIAL FATTY ACID BETA OXIDATION 1.8/4.4 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition IC50 (μM) 333
SYNTHESIS OF KETONE BODY 5.6 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition IC50 (μM) 333

  • B847-47 dechloroetomoxir