Does an inhibitor of mitochondrial adenylate kinase also affect oxidative phosphorylation?
Authors
L?storff, J; Schlimme, E
| Publication Year | 1976 |
| Journal | Experientia |
| Chapter | |
| Pages | 298-299 |
| Volume | 32 |
| Issue | 3 |
| Issn | |
| Isbn | |
| PMID | 176055.0 |
| PMCID | |
| DOI | 10.1007/BF01940801 |
| URL | http://dx.doi.org/10.1007/BF01940801 |
Adenylate kinase activity of intact mitochondria is strongly inhibited by Ap5A, i.e. p1,p5-Di (adenosine-5') pentaphosphate, whereas oxidative phosphorylation is not affected. Therefore, Ap5A is a useful tool to distinguish between oxidative and non oxidative ATP generating reactions.