T027001 Source: Uniprot
enzymeLong-chain-fatty-acid--CoA ligase 1
(ACSL1)
Ligase
Long-chain-fatty-acid--CoA ligase >>
| Full Name | Long-chain-fatty-acid--CoA ligase 1 |
|---|---|
| Protein Names | Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24) |
| Subcellular Location | Endoplasmic reticulum membrane Microsome membrane Mitochondrion outer membrane Peroxisome membrane Single-pass type III membrane protein |
| EC numbers | 6.2.1.3; 6.2.1.15; 6.2.1.24 |
| Uniprot Accession | P33121 |
| Uniprot Name | ACSL1_HUMAN |
| Gene symbol | ACSL1 |
| Gene Name | Acyl-CoA synthetase long chain family member 1 |
| Ensembl | ENSG00000151726 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Perhexiline | 200 μM | mouse; Crl/CD-l(1CR)BR Swiss | liver mitochondria | Measurement of activity of long-chain fatty acyl-CoA synthetase | Negative | p < 0.05 | 193 | |
| Perhexiline | 400 μM | mouse; Crl/CD-l(1CR)BR Swiss | liver mitochondria | Measurement of activity of long-chain fatty acyl-CoA synthetase | Negative | p < 0.05 | 193 | |