T027001 Source: Uniprot

enzymeLong-chain-fatty-acid--CoA ligase 1 (ACSL1)
Ligase
Long-chain-fatty-acid--CoA ligase >>
Full Name Long-chain-fatty-acid--CoA ligase 1
Protein Names Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)
Subcellular Location Endoplasmic reticulum membrane Microsome membrane Mitochondrion outer membrane Peroxisome membrane Single-pass type III membrane protein
EC numbers 6.2.1.3; 6.2.1.15; 6.2.1.24
Uniprot Accession P33121
Uniprot Name ACSL1_HUMAN
Gene symbol ACSL1
Gene Name Acyl-CoA synthetase long chain family member 1
Ensembl ENSG00000151726

Compound Dose Time Species Model Method Result Positive criterion Reference
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
Perhexiline 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193