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T028 Source: Uniprot

enzymeShort-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD)
Oxidoreductase
Full Name Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Protein Names Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)
Subcellular Location Mitochondrion matrix
EC numbers 1.3.8.1
Uniprot Accession P16219
Uniprot Name ACADS_HUMAN
Gene symbol ACADS
Gene Name Acyl-CoA dehydrogenase short chain
Ensembl ENSG00000122971

Compound Dose Time Species Model Method Result Positive criterion Reference
Perhexiline 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Perhexiline 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Perhexiline 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.05 193

F02060101. mitochondrial fatty acid beta oxidation