Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)

T029 Source: Uniprot

enzymeMedium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD)
Oxidoreductase
Full Name Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Protein Names Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7)
Subcellular Location Mitochondrion matrix
EC numbers 1.3.8.7
Uniprot Accession P11310
Uniprot Name ACADM_HUMAN
Gene symbol ACADM
Gene Name Acyl-CoA dehydrogenase medium chain
Ensembl ENSG00000117054

Compound Dose Time Species Model Method Result Positive criterion Reference
Perhexiline 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Perhexiline 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193

F02060101. mitochondrial fatty acid beta oxidation