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T030 Source: Uniprot

enzymeLong-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD)
Oxidoreductase
Full Name Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Protein Names Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)
Subcellular Location Mitochondrion matrix
EC numbers 1.3.8.8
Uniprot Accession P28330
Uniprot Name ACADL_HUMAN
Gene symbol ACADL
Gene Name Acyl-CoA dehydrogenase long chain
Ensembl ENSG00000115361

Compound Dose Time Species Model Method Result Positive criterion Reference
Perhexiline 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Perhexiline 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Perhexiline 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193
Perhexiline 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Positive p < 0.01 193

F02060101. mitochondrial fatty acid beta oxidation