T227
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Diclofenac | 50 μmol/L | 10 minutes | rat | liver mitochondria | Assay of Mitochondrial Protein Thiol; Assay of Mitochondrial GSH; incubated in the absence of Ca2+ | Negative | p < 0.05 | 6 |
| Diclofenac | 50 μmol/L | 10 minutes | rat | liver mitochondria | Assay of Mitochondrial Protein Thiol; Assay of Mitochondrial GSH; incubated in the presence of Ca2+ | Positive | p < 0.01 | 6 |