T231 Source: Uniprot
enzymeDNA-directed RNA polymerase, mitochondrial
(MtRPOL)
Nucleotidyltransferase
Transferase
| Full Name | DNA-directed RNA polymerase, mitochondrial |
|---|---|
| Protein Names | DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) |
| Subcellular Location | Mitochondrion |
| EC numbers | 2.7.7.6 |
| Uniprot Accession | O00411 |
| Uniprot Name | RPOM_HUMAN |
| Gene symbol | POLRMT |
| Gene Name | RNA polymerase mitochondrial |
| Ensembl | ENSG00000099821 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| LDC203974 | 10 μM | 6hr | HeLa cells | Mitochondrial transcript levels of ND1 and CYTB | Positive | 314 | ||
| LDC203974 | 0–10 μM | Single nucleotide incorporation assays at varying ATP concentrations | Positive | Vmax app, maximum reaction rate; Km app, substrate affinity | 314 | |||
| LDC203974 | 743nM | Microscale thermophoresis binding curves in the absence or presence of 10 μM IMT1B | Positive | Kd | 314 | |||