T231 Source: Uniprot

enzymeDNA-directed RNA polymerase, mitochondrial (MtRPOL)
Nucleotidyltransferase Transferase
Full Name DNA-directed RNA polymerase, mitochondrial
Protein Names DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC
Subcellular Location Mitochondrion
EC numbers
Uniprot Accession O00411
Uniprot Name RPOM_HUMAN
Gene symbol POLRMT
Gene Name RNA polymerase mitochondrial
Ensembl ENSG00000099821

Compound Dose Time Species Model Method Result Positive criterion Reference
LDC203974 10 μM 6hr HeLa cells Mitochondrial transcript levels of ND1 and CYTB Positive 314
LDC203974 0–10 μM Single nucleotide incorporation assays at varying ATP concentrations Positive Vmax app, maximum reaction rate; Km app, substrate affinity 314
LDC203974 743nM Microscale thermophoresis binding curves in the absence or presence of 10 μM IMT1B Positive Kd 314