Regulator

Full Name	Apoptosis regulator BAX
Protein Names	Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Subcellular Location	Cytoplasm Single-pass membrane protein [Isoform Alpha]: Mitochondrion outer membrane [Isoform Beta]: Cytoplasm [Isoform Delta]: Cytoplasm [Isoform Gamma]: Cytoplasm
Uniprot Accession	Q07812
Uniprot Name	BAX_HUMAN
Gene symbol	BAX
Gene Name	BCL2 associated X, apoptosis regulator
Ensembl	ENSG00000087088

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
Clotrimazole	150 mg/kg/day	6 days a week for two weeks	human	CAL27(xenograft tumors)/mouse	western blot analysis	Positive	2.0-fold increase	5
Clotrimazole	40 µM	12 hours	human	CAL27	western blot	Positive	1.3953-fold increase	5
Clotrimazole	40 µM	12 hours	human	UM1	western blot	Negative	No increase	5
Clotrimazole	40 µM	24 hours	human	CAL27	western blot	Positive	1.3953-fold increase	5
Clotrimazole	40 µM	24 hours	human	UM1	western blot	Positive	1.2623-fold increase	5
Clotrimazole	40 µM	48 hours	human	CAL27	western blot	Positive	2.3256-fold increase	5
Clotrimazole	40 µM	48 hours	human	UM1	western blot	Positive	1.6223-fold increase	5

Associated Functions

F0701. Apoptosis