Transporter

Full Name	Calcium uptake protein 1, mitochondrial
Protein Names	Calcium uptake protein 1, mitochondrial (Atopy-related autoantigen CALC) (ara CALC) (Calcium-binding atopy-related autoantigen 1) (allergen Hom s 4)
Subcellular Location	Mitochondrion inner membrane Mitochondrion intermembrane space Single-pass membrane protein
Uniprot Accession	Q9BPX6
Uniprot Name	MICU1_HUMAN
Gene symbol	MICU1
Gene Name	Mitochondrial calcium uptake 1
Ensembl	ENSG00000107745

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
MCU-i11	5 μM			HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine	Highigh-throughput screening assay based on aequorin.	Positive		301
MCU-i4	8.4 μM(Micu1), 18 μM (Micu1-Micu2)			Purified recombinant Micu1, Micu2	Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface.	Positive	IC50	301
MCU-i11	2.9 μM(Micu1), 2.7 μM (Micu1-Micu2)			Purified recombinant Micu1, Micu2	Purified recombinant Micu1, Micu2, and the dimeric Micu1-Micu2 proteins were immobilized on different channels of a SPR sensor chip surface.	Positive	IC50	301
MCU-i4	5 μM			HeLa cells transfected with mitochondria-targeted aequorin (mtAeq) after cellular stimulation with histamine	Highigh-throughput screening assay based on aequorin.	Positive		301

Associated Functions

F02110301. transport of calcium