Drug
D0030 | Clofibrate
C
C10AB01 Clofibrate
[C10AB] Fibrates
[C10A] LIPID MODIFYING AGENTS, PLAIN
[C10] LIPID MODIFYING AGENTS
[C] Cardiovascular system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| OXIDATIVE STRESS | 185 | |||||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (97.5%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (97.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | unreported | 1500mg/kg (1500mg/kg) | United States Patent Document. Vol. #4412998, | |
| man | TDLo | oral | 1071ug/kg (1.071mg/kg) | behavioral: tremor | Neurology. Vol. 37, Pg. 881, 1987. |
| mouse | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981. | |
| guinea pig | LD50 | oral | 1280mg/kg (1280mg/kg) | Drugs of the Future. Vol. 4, Pg. 140, 1979. | |
| hamster | LD50 | oral | 2400mg/kg (2400mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981. | |
| mouse | LD50 | unreported | 1500mg/kg (1500mg/kg) | British UK Patent Application. Vol. #2041937, | |
| mammal (species unspecified) | LD50 | oral | 3gm/kg (3000mg/kg) | Drugs of the Future. Vol. 4, Pg. 140, 1979. | |
| hamster | LD50 | intraperitoneal | 1260mg/kg (1260mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981. | |
| man | TDLo | oral | 171mg/kg/6D-I (171mg/kg) | Israel Journal of Medical Sciences. Vol. 20, Pg. 1082, 1984. | |
| mouse | LD50 | intravenous | > 500mg/kg (500mg/kg) | Drugs in Japan Vol. -, Pg. 341, 1990. | |
| mouse | LD50 | oral | 1220mg/kg (1220mg/kg) | Chemical and Pharmaceutical Bulletin. Vol. 32, Pg. 1568, 1984. | |
| rabbit | LD50 | oral | 1370mg/kg (1370mg/kg) | Drugs of the Future. Vol. 4, Pg. 140, 1979. | |
| rat | LD50 | intraperitoneal | 910mg/kg (910mg/kg) | Journal Europeen de Toxicologie. Vol. 5, Pg. 239, 1972. | |
| rat | LD50 | oral | 940mg/kg (940mg/kg) | Archivos de Farmacologia y Toxicologia. Vol. 6, Pg. 255, 1980. | |
| women | TDLo | oral | 80mg/kg/2D-I (80mg/kg) | New England Journal of Medicine. Vol. 301, Pg. 1345, 1979. | |
| man | TDLo | oral | 4232mg/kg/57W (4232mg/kg) | Japanese Journal of Medicine. Vol. 29, Pg. 545, 1990. | |
| .alpha.-(p-Chlorophenoxy)isobutyric acid, ethyl ester | .alpha.-p-Chlorophenoxyisobutyryl ethyl ester | 19 more names available |
| 2-(4-Chloro-phenoxy)-2-methyl-propionic acid ethyl ester | 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester | 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester |
| 2-(4-Chlorophenoxy)isobutyric Acid Ethyl Ester | 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester | 2-(p-Chlorophenoxy)isobutyric acid ethyl ester |
| 2-(p-chlorophenoxy)-2-methylPropanoic acid ethyl ester | 2-(p-chlorophenoxy)-2-methylpropionic acid ethyl ester; | 637-07-0 |
| A834483 | AB00052358-07 | AB00052358-08 |
| AB00052358_09 | AB00052358_10 | AB0013973 |
| AB2000309 | AK01050740 | AKOS015889383 |
| ANW-42230 | API0025998 | AS-14127 |
| ATROMID-S (TN) | AY 61123 | AY-61123 |
| Abitrate | Acetic acid, (p-chlorophenoxy)dimethyl-, ethyl este | Acetic acid, (p-chlorophenoxy)dimethyl-, ethyl ester |
| Amotril | Amotril S | Angiokapsul |
| Anparton | Antilipid | Antilipide |
| Apolan | Arterioflexin | Arterosol |
| Artes | Artevil | Ateculon |
| Ateriosan | Athebrate | Atheromide |
| Atheropront | Athranid-wirkstoff | Atrolen |
| Atromid | Atromid S | Atromid-S |
| Atromida | Atromidin | Atrovis |
| Azionyl | BCBcMAP01_000104 | BDBM50085047 |
| BG0148 | BIDD:GT0172 | BIDD:PXR0178 |
| BML2-F02 | BRN 1913459 | BSPBio_001577 |
| Bio1_000146 | Bio1_000635 | Bio1_001124 |
| Bio2_000297 | Bio2_000777 | Bioscleran |
| Bresit | C 6643 | C-14662 |
| C06916 | C12H15ClO3 | CAS-637-07-0 |
| CBiol_001860 | CC-05772 | CCG-40281 |
| CCRIS 177 | CHEBI:3750 | CHEMBL565 |
| CPIB | CS-2300 | CTK3J2220 |
| Cartagyl | Chlorfenisate | Chlorphenisate |
| Cinnarizin | Citiflus | Claripex |
| Claripex CPIB | Cloberat | Clobrat |
| Clobren SF | Clobren-5F | Clobren-SF |
| Clofar | Clofibate | Clofibram |
| Clofibrat | Clofibrate (JP17/USP/INN) | Clofibrate [USAN:INN:BAN:JAN] |
| Clofibrate [USAN:USP:INN:BAN:JAN] | Clofibrate liquid | Clofibrate(Atromid-S) |
| Clofibrate, >=98.0% (GC) | Clofibrate, European Pharmacopoeia (EP) Reference Standard | Clofibrate, United States Pharmacopeia (USP) Reference Standard |
| Clofibrate, analytical reference material | Clofibrate, liquid | Clofibrato |
| Clofibrato [INN-Spanish] | Clofibrato [Spanish] | Clofibratum |
| Clofibratum [INN-Latin] | Clofibric Acid, Ethyl Ester | Clofinit |
| Clofipront | D00279 | DB-054528 |
| DB00636 | DSSTox_CID_336 | DSSTox_GSID_20336 |
| DSSTox_RID_75521 | DTXSID3020336 | Delipid |
| Deliva | DivK1c_000822 | DivK1c_000926 |
| Dura clofibrat | EBD52899 | EINECS 211-277-4 |
| ELPI | EN300-119182 | EPIB |
| EU-0100306 | Ethyl .alpha.-(4-chlorophenoxy)-.alpha.-methylpropionate | Ethyl .alpha.-(4-chlorophenoxy)isobutyrate |
| Ethyl .alpha.-(p-chlorophenoxy)-.alpha.-methylpropionate | Ethyl .alpha.-(p-chlorophenoxy)isobutyrate | Ethyl .alpha.-p-(chlorophenoxy)isobutyrate |
| Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate # | Ethyl 2-(4-chlorophenoxy)-2-methylpropionate |
| Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, 99% | Ethyl 2-(4-chlorophenoxy)isobutyrate | Ethyl 2-(p-chlorophenoxy)-2-methylpropionate |
| Ethyl 2-(p-chlorophenoxy)isobutyrate | Ethyl 2-(para-chlorophenoxy)-2-methylpropionate (IUPAC) | Ethyl alpha-(4-chlorophenoxy)-alpha-methylpropionate |
| Ethyl alpha-(4-chlorophenoxy)isobutyrate | Ethyl alpha-(p-Chlorophenoxy)-alpha-methylpropionate | Ethyl alpha-(p-chlorophenoxy)isobutyrate |
| Ethyl alpha-p-chlorophenoxyisobutyrate | Ethyl chlorophenoxyisobutyrate | Ethyl clofibrate |
| Ethyl p-chlorophenoxyisobutyrate | Ethyl para-chlorophenoxyisobutyrate | Ethyl-alpha-p-chlorophenoxy-isobutyrate |
| FT-0625865 | Fibralem | GTPL2667 |
| Gerastop | HMS1361O19 | HMS1791O19 |
| HMS1989O19 | HMS2089P03 | HMS2093G07 |
| HMS2233C17 | HMS3260N14 | HMS3373C06 |
| HMS3402O19 | HMS3715J03 | HMS502J04 |
| HMS502O08 | HPN91K7FU3 | HSDB 3038 |
| HY-B0287 | Hyclorate | ICI 28257 |
| ICI-28257 | IDI1_000822 | IDI1_000926 |
| IDI1_034047 | Isobutyric acid, .alpha.-(p-chlorophenoxy)-, ethyl ester | Isobutyric acid, alpha-(p-chlorophenoxy)-, ethyl ester |
| K009 | KBio1_000822 | KBio1_000926 |
| KBio2_000297 | KBio2_002215 | KBio2_002865 |
| KBio2_004783 | KBio2_005433 | KBio2_007351 |
| KBio3_000593 | KBio3_000594 | KBioGR_000297 |
| KBioGR_000885 | KBioSS_000297 | KBioSS_002215 |
| KNHUKKLJHYUCFP-UHFFFAOYSA-N | KS-00000X36 | KSC492E2B |
| Klofibrat | Klofiran | LP00306 |
| LS-7282 | Levatrom | Lipamid |
| Lipavil | Lipavlon | Lipide 500 |
| Lipidsenker | Lipofacton | Lipomid |
| Liponorm | Liporeduct | Liporil |
| Liposid | Liprin | Liprinal |
| Lobetrin | Lopac-C-6643 | Lopac0_000306 |
| MCULE-9236719628 | MFCD00000615 | MLS001336011 |
| MLS001336012 | MLS002153494 | Miscleron |
| Misclerone | Miskleron | NCGC00015257-01 |
| NCGC00015257-02 | NCGC00015257-03 | NCGC00015257-04 |
| NCGC00015257-05 | NCGC00015257-06 | NCGC00015257-07 |
| NCGC00015257-08 | NCGC00015257-09 | NCGC00015257-10 |
| NCGC00015257-11 | NCGC00015257-12 | NCGC00015257-14 |
| NCGC00093755-01 | NCGC00093755-03 | NCGC00093755-04 |
| NCGC00093755-05 | NCGC00093755-06 | NCGC00093755-07 |
| NCGC00093755-08 | NCGC00254073-01 | NCGC00259963-01 |
| NCGC00260991-01 | NCI60_041748 | NCIOpen2_004739 |
| NE29896 | NINDS_000822 | NINDS_000926 |
| NSC 79389 | NSC-758474 | NSC-79389 |
| NSC758474 | NSC79389 | Negalip |
| Neo-Atromid | Normalip | Normat |
| Normet | Normolipol | OR26850 |
| Oxan 600 | Persantinat | Pharmakon1600-01503429 |
| Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester | Propanoic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester | Propionic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester |
| Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester | Q2701912 | RTR-021904 |
| Recolip | Regardin | Regelan |
| Regelan N | Robigram | SBB099633 |
| SBI-0050294.P003 | SCHEMBL2356 | SMR000058279 |
| SPBio_000998 | SR-01000075544 | SR-01000075544-1 |
| SR-01000075544-4 | SR-01000075544-5 | SR-01000075544-8 |
| ST50319977 | Scrobin | Serofinex |
| Serotinex | Skerolip | Sklerepmexe |
| Sklero | Sklero-Tablinen | Sklero-tablinene |
| Sklero-tabuls | Sklerolip | Skleromex |
| Skleromexe | Spectrum2_001209 | Spectrum4_000223 |
| Spectrum5_001133 | Spectrum_001735 | TR-021904 |
| Ticlobran | Tox21_110116 | Tox21_110116_1 |
| Tox21_202414 | Tox21_300277 | Tox21_500306 |
| UNII-HPN91K7FU3 | UPCMLD-DP019 | UPCMLD-DP019:001 |
| Vincamin compositum | WLN: GR DOX1&1&VO2 | Xyduril |
| Yoclo | Z53835984 | ZINC56648 |
| ZX-AT020414 | alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester | alpha-p-Chlorophenoxyisobutyryl ethyl ester |
| clofibrate | clofibrate (CLOF) | ethyl 2-(4-chloranylphenoxy)-2-methyl-propanoate |
| ethyl 2-(4-chlorophenoxy)-2-methyl-propanoate | ethyl 2-[(4-chlorophenyl)oxy]-2-methylpropanoate | neo-Atomid |
| p-Chlorophenoxyisobutyric acid ethyl ester |
| DrugBank Name | Clofibrate |
| DrugBank | DB00636 |
| CAS Number | 1016163-79-3, 18671-89-1, 637-07-0 |
| PubChem Compound | 2796 |
| KEGG Compound ID | C06916 |
| KEGG Drug | D00279 |
| PubChem.Substance | 46504748 |
| ChEBI | 3750 |
| PharmGKB | PA449045 |
| ChemSpider | 2694 |
| BindingDB | 50085047.0 |
| TTD | DAP000262 |
| Wikipedia | Clofibrate |
| DPD | 9842 |
1. Chan et al. (2005)
2. Qu et al. (2001)
3. Zhou et al. (1999)
4. Brunmair et al. (2004)