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Drug

D0063 | Gemfibrozil

Molecular Formula C15H22O3
Molecular Weight 250.33
Structure
State solid
Route of elimination Approximately seventy percent of the administered human dose is excreted in the urine, mostly as the glucuronide conjugate, with less than 2% excreted as unchanged gemfibrozil.
Protein binding 0.95
Half life 1.5 hours
Absorption Well absorbed from gastrointestinal tract (within 1-2 hours).

C

C10AB04 Gemfibrozil


[C10AB] Fibrates


[C10A] LIPID MODIFYING AGENTS, PLAIN


[C10] LIPID MODIFYING AGENTS


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53
ELECTRON TRANSPORT CHAIN isolated mitochondria decrease 7
ELECTRON TRANSPORT CHAIN rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay Negative 53

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase isolated mitochondria inhibitor 7

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 131 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 131 companies. For more detailed information, please visit ECHA C&L website


Of the 9 notification(s) provided by 130 of 131 companies with hazard statement code(s):


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H351 (24.62%): Suspected of causing cancer [Warning Carcinogenicity]


H361 (26.15%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H411 (24.62%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P264, P270, P273, P281, P301+P312, P308+P313, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H350 (100%): May cause cancer [Danger Carcinogenicity]


H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


 P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Abdominal pain

  • Acute coronary syndrome

  • Blood triglycerides increased

  • Combined hyperlipidaemia

  • Coronary artery disease

  • Dyslipidaemia

  • Fasting

  • Gastrointestinal pain

  • Hypercholesterolaemia

  • Hypothyroidism

  • Low density lipoprotein increased

  • Myocardial infarction

  • Pancreatitis

  • Type IV hyperlipidaemia

  • Type V hyperlipidaemia

  • Weight decreased

  • Xanthoma

  • Abdominal pain

  • Abdominal pain upper

  • Appendicitis

  • Asthenia

  • Atrial fibrillation

  • Chest pain

  • Constipation

  • Dermatitis

  • Diarrhoea

  • Dizziness

  • Dyspepsia

  • Eczema

  • Fatigue

  • Flatulence

  • Gastrointestinal disorder

  • Gastrointestinal pain

  • Gout

  • Headache

  • Musculoskeletal pain

  • Nausea

  • Pain

  • Paraesthesia

  • Pruritus

  • Rash

  • Urticaria

  • Vertigo

  • Vision blurred

  • Vomiting

    • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
    2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeric Acid 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
    2,2-Dimethyl-5-(2,5-zlyloxy)valeric acid 25812-30-0 4TX
    5-(2,5-Dimethyl-Phenoxy)-2,2-Dimethyl-Pentanoic Acid 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid 5-(2,5-dimethylphenoxy)-2,2-
    5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid 5-[(2,5-dimethylphenyl)oxy]-2,2-dimethylpentanoic acid A0G461
    A818037 AB00052003 AB00052003-15
    AB00052003-16 AB00052003_17 AB00052003_18
    AB0013344 AB03034 AB2000253
    AC-4225 AK309283 AKOS001606691
    API0002816 ARONIS24091 AX8032912
    Apo-Gemfibrozil Ausgem BBC/228
    BBL010807 BB_SC-04837 BCP08437
    BDBM50110590 BG0205 BPBio1_000251
    BRD-K11129031-001-05-1 BRN 1881200 BSPBio_000227
    BSPBio_002060 Bolutol Brozil
    C-15436 C07020 CAS-25812-30-0
    CC-28946 CCG-40111 CCRIS 318
    CG0035 CHEBI:5296 CHEMBL457
    CI 719 CI-719 CPD000058393
    CS-2244 Certified Reference Material Cholespid
    Clearol D00334 DB01241
    DL-414 DSSTox_CID_652 DSSTox_GSID_20652
    DSSTox_RID_75712 DTXSID0020652 Decrelip
    DivK1c_000138 EINECS 247-280-2 Elmogan
    FT-0626641 FT-0700924 Fetinor
    Fibratol Fibrocit G0368
    GEMFIBROZIL (SEE ALSO PEROXISOME PROJECT (GEMFIBROZIL)) GP1460 GTPL3439
    Gem-S Gemcor Gemcor;Jezil;Gen-Fibro;Lopid
    Gemd Gemfibril Gemfibromax
    Gemfibrosil Gemfibrozil (JAN/USP/INN) Gemfibrozil (Lopid)
    Gemfibrozil [USAN:BAN:INN] Gemfibrozil [USAN:USP:INN:BAN] Gemfibrozil for system suitability, European Pharmacopoeia (EP) Reference Standard
    Gemfibrozil(Lopid) Gemfibrozil, 98% Gemfibrozil, British Pharmacopoeia (BP) Reference Standard
    Gemfibrozil, European Pharmacopoeia (EP) Reference Standard Gemfibrozil, Pharmaceutical Secondary Standard Gemfibrozil, United States Pharmacopeia (USP) Reference Standard
    Gemfibrozil, analytical standard Gemfibrozil,(S) Gemfibrozilo
    Gemfibrozilo [INN-Spanish] Gemfibrozilum Gemfibrozilum [INN-Latin]
    Gemlipid Gemnpid Gen-Fibro
    Gevilon Uno Gozid H900
    HEMJJKBWTPKOJG-UHFFFAOYSA-N HMS1568L09 HMS1920B07
    HMS2090K14 HMS2091H11 HMS2095L09
    HMS2230H24 HMS3259M12 HMS3655C06
    HMS3712L09 HMS500G20 HSDB 7735
    HY-B0258 Hidil Hipolixan
    IDI1_000138 Innogem Innogen
    Ipolipid J10068 Jezil
    KBio1_000138 KBio2_001305 KBio2_003873
    KBio2_006441 KBio3_001280 KBioGR_000964
    KBioSS_001305 KS-00000VK6 KS-000046JO
    KS-5192 LS-1085 Lanaterom
    Lifibron Lipazil Lipigem
    Lipira Lipizyl Lipozid
    Lipur Litarek Lopid
    Lopid (TN) Lopid R Low-Lip
    MCULE-4563546953 MFCD00079335 MLS000028421
    MLS001055364 MLS006011850 Micolip
    NC00565 NCGC00016794-01 NCGC00016794-02
    NCGC00016794-03 NCGC00016794-04 NCGC00016794-05
    NCGC00016794-06 NCGC00016794-07 NCGC00016794-08
    NCGC00016794-09 NCGC00016794-10 NCGC00016794-11
    NCGC00016794-13 NCGC00016794-14 NCGC00022722-03
    NCGC00022722-04 NCGC00022722-05 NCGC00022722-06
    NCGC00022722-07 NCGC00256601-01 NCGC00259546-01
    NINDS_000138 NSC-757024 NSC757024
    Normolip Opera_ID_1658 PEROXISOME PROJECT (GEMFIBROZIL) (SEE ALSO GEMFIBROZIL)
    Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- Pharmakon1600-10500313 Pilder
    Polyxit Prestwick0_000214 Prestwick1_000214
    Prestwick2_000214 Prestwick3_000214 Prestwick_637
    Progemzal Q384295 Q8X02027X3
    Reducel Regulip Renabrazin
    SAM002564211 SBB012457 SBI-0051391.P003
    SC-17669 SCHEMBL4813 SEL11160931
    SMR000058393 SPBio_001174 SPBio_002148
    SPECTRUM1500313 SR-01000000056 SR-01000000056-3
    SR-01000000056-4 SR-01000000056-6 SR-01000000056-7
    ST072198 STK618740 SW196802-3
    Sinelip Spectrum2_001097 Spectrum3_000440
    Spectrum4_000562 Spectrum5_000750 Spectrum5_001991
    Spectrum_000825 Synbrozil TEVA-A
    Taborcil Tentroc Tox21_110613
    Tox21_110613_1 Tox21_201997 Tox21_302784
    Trialmin UNII-Q8X02027X3 VA11004
    Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)- W-107216 WL-Gemfibrozil
    Z-0832 ZINC1530641 ZX-AS004442
    dimethylpentanoic acid gemfibrozil s1729

    DrugBank Name Gemfibrozil
    DrugBank DB01241
    CAS Number 114413-98-8, 25812-30-0
    PubChem Compound 3463
    KEGG Compound ID C07020
    KEGG Drug D00334
    PubChem.Substance 46508264
    ChEBI 5296
    PharmGKB PA449750
    ChemSpider 3345
    BindingDB 50110590.0
    TTD DAP000210
    Wikipedia Gemfibrozil
    HET 4TX
    DPD 1904

    1. Brunmair et al. (2004)
    2. Zhou et al. (1999)