F020103 | Electron transport chain

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Pioglitazone decrease Positive 22
Chlorpromazine rat isolated liver mitochondria decrease Positive 23
Haloperidol rat isolated liver mitochondria decrease Positive 23
Risperidone rat isolated liver mitochondria decrease Positive 23
quetiapine rat isolated liver mitochondria decrease Positive 23
Antimycin A decrease Positive 26
Myxothiazol bovine heart mitochondria decrease Positive 29
Papaverine decrease Positive 30
Thenoyltrifluoroacetone decrease Positive 33
Acetaminophen decrease Positive 35
Acetaminophen decrease Positive 35
Acetylsalicylic acid decrease Positive 35
Acetylsalicylic acid decrease Positive 35
Flutamide decrease Positive 35
Ketoconazole decrease Positive 35
mefloquine decrease Positive 35
Metformin decrease Positive 35
Nefazodone decrease Positive 35
Nitrofurantoin decrease Positive 35
Paraquat decrease Positive 35
paroxetine decrease Positive 35
paroxetine decrease Positive 35
paroxetine decrease Positive 35
paroxetine decrease Positive 35
Phenformin decrease Positive 35
Pioglitazone decrease Positive 35
Pioglitazone decrease Positive 35
promethazine decrease Positive 35
Rosiglitazone decrease Positive 35
Rotenone decrease Positive 35
Tamoxifen decrease Positive 35
Tamoxifen decrease Positive 35
Tamoxifen decrease Positive 35
Tamoxifen decrease Positive 35
Troglitazone decrease Positive 35
Antimycin A decrease Positive 35
Myxothiazol decrease Positive 35
Oligomycin decrease Positive 35
Thenoyltrifluoroacetone decrease Positive 35
alpidem decrease Positive 36
Amiodarone decrease Positive 36
benzbromarone decrease Positive 37
Chlorpromazine decrease Positive 7
clomipramine decrease Positive 38
Diclofenac decrease Positive 39
Flutamide decrease Positive 41
Ketoconazole decrease Positive 36
lovastatin decrease Positive 36
Phenformin decrease Positive 43
Rosiglitazone decrease Positive 7
Simvastatin decrease Positive 7
sitaxsentan decrease Positive 44
Tamoxifen decrease Positive 46
Troglitazone decrease Positive 7
Doxorubicin decrease Positive 36
imipramine decrease Positive 36
sertraline decrease Positive 48
zoniporide decrease Positive 50
pentamidine decrease Positive 51
ritonavir decrease Positive 36
Tenofovir decrease Positive 52
Polymyxin B rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
beclomethasone rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
bicalutamide rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
danazol rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
ethynodiol diacetate rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
retinoic acid rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
aripiprazole rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
axitinib rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
clofilium rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
tenidap rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
darifenacin rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
pimozide rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay decrease Positive 53
Gemfibrozil isolated mitochondria decrease Positive 7
Amitriptyline pig brain mitochondria decrease Positive 60
citalopram pig brain mitochondria decrease Positive 62
citalopram pig brain mitochondria decrease Positive 62
citalopram pig brain mitochondria decrease Positive 62
Haloperidol decrease Positive 23
propranolol pig brain mitochondria decrease Positive 60
Indomethacin rat isolated liver mitochondria decrease Positive 65
ochratoxin a rat isolated liver mitochondria decrease Positive 66
tacrolimus rat isolated kidney mitochondria decrease Positive 68
Piericidin A affect Positive 53
rolliniastatin-2 affect Positive 53
Idebenone affect Positive 53
Rotenone affect Positive 53
piericidin a affect Positive 53
piericidin b affect Positive 53
aureothin affect Positive 53
amytal affect Positive 53
4-alkyl-acridones affect Positive 53
4′-alkyl-mpp+ analoguesc affect Positive 53
phenoxan affect Positive 53
quinol products affect Positive 53
reduced q-2b affect Positive 53
Myxothiazol affect Positive 53
stigmatellin affect Positive 53
TDS affect Positive 53
2M-TIO affect Positive 53
meperidine affect Positive 53
para-nonylphenol affect Positive 53
Diphenyleneiodonium chloride affect Positive 69
ethoxyformic anhydride affect Positive 70
ethoxyformic anhydride decrease Positive 70
ethoxyformic anhydride decrease Positive 70
flutolanil affect Positive 71
atpenin a5 affect Positive 71
Carboxin affect Positive 71
penthiopyrad affect Positive 71
boscalid affect Positive 71
fluopyram affect Positive 71
dinitrophenol-17 affect Positive 71
atpenin a5 affect Positive 72
thiophene carboxamides affect Positive 73
HQNO affect Positive 74
Polymyxin B 1.6 μg/ml Mycobacterium smegmatis membrane-bound dehydrogenases decrease Positive IC50 76
nanaomycin a 31 μg/ml Mycobacterium smegmatis membrane-bound dehydrogenases decrease Positive IC50 76
siccanin P. aeruginosa PAO1 cells affect Positive 76
cyenopyrafen affect Positive 77
pyflubumide affect Positive 77
3-Nitropropionate affect Positive 78
Malonate affect Positive 79
british anti-lewisite affect Positive 80
Myxothiazol affect Positive 81
moas affect Positive 82
azoxystrobin affect Positive 83
oudemansin a affect Positive 84
strobilurin a affect Positive 84
cpmb-oxime affect Positive 84
azoxystrobin 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
famoxadone 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
stigmatellin 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
uhdbt 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
hhdbt uhnq 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
dibromothymoquinone 100 mM incubated overnight bovine isolated heart mitochondria Measurements of redox potentials of the ISP affect Positive 83
Antimycin A bovine isolated heart mitochondria cytochrome bc1 complex affect Positive 166
diuron affect Positive 83
NQNO bovine isolated heart mitochondria cytochrome bc1 complex affect Positive 166
NQNO bovine isolated heart mitochondria cytochrome bc1 complex affect Positive 166
Carbon Monoxide affect Positive 167
nitric oxide affect Positive 167
Cyanide affect Positive 167
azides affect Positive 167
sulfide affect Positive 167
formate affect Positive 167
ethylxanthate affect Positive 167
bisulfate affect Positive 167
semicarbazide affect Positive 167
salicyaldoxime affect Positive 167
ethylxanthate decrease Positive 167
bisulfate decrease Positive 167
semicarbazide decrease Positive 167
salicyaldoxime decrease Positive 167
adda 5 human U251 mitochondria CcO activity assay affect Positive 168
tetrathiomolybdate 30 μM 48 hour human ECC-1 affect Positive 169
tetrathiomolybdate 30 μM 48 hour human IGROV-1 affect Positive 169
Oligomycin 152 μg inhibitor/mg protein E. coli membrane vesicle, pH gradient formation affect Positive 170
Oligomycin 7.1 μg inhibitor/mg protein C. asciculate SMP-ATPase affect Positive IC50 170
Oligomycin 2.0-3.0 μg inhibitor/mg protein S. cerevisiae SMP-ATPase affect Positive IC50 170
Oligomycin 0.3 μM human NCI-60 cell lines F0F1-ATPase affect Positive IC50 170
Oligomycin 15 ng inhibitor/mg protein N. crassa SMP-ATPase affect Positive Ki 170
Oligomycin 0.21 μM bovine heart MF0F1-ATPase affect Positive Ki 170
Oligomycin 0.4 μg inhibitor/mg protein bovine heart SMP-ATPase affect Positive 95% inhibition 170
Oligomycin 0.5 μg/ml rat liver SMP-ATPase affect Positive 75% inhibition 170
ossamycin 46 μg of inhibitor/mg protein E. coli pH gradient formation by membrane vesicle affect Positive IC50 170
ossamycin 8 μM human NCI-60 cell lines F0F1-ATPase affect Positive IC50 170
ossamycin 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase affect Positive IC50 170
venturicidin B affect Positive 170
Bedaquiline affect Positive 170
tributyltin chloride 200 nM E. coli and F0F1-ATPase affect Positive 170
tributyltin chloride 200 nM I. tartaricus F0F1-ATPase affect Positive 170
tributyltin chloride 1 μM C. thermoaceticum membrane-bound F0F1-ATPase affect Positive 47% inhibition 170
tributyltin chloride 5 μM C. thermoaceticum membrane-bound F0F1-ATPase affect Positive 87% inhibition 170
tributyltin chloride 1 μM TF0F1-ATPase affect Positive 80% inhibition 170
NCCD 0.65 nmol/mg protein bovine heart SMP-ATPase affect Positive IC50 170
NCCD 1 nmol NCCD/mg protein bovine heart SMP-ATPase affect Positive 85% inhibition 170
substrate analogs affect Positive 170
tentoxin ∼0.6 mol/mol spinach CF1-ATPase affect Positive IC50 170
tentoxin 50 nM spinach CF1(-ɛ)-ATPase affect Positive IC50 170
tentoxin 0.4-0.6 μM lettuce chloroplasts, photophosphorylation affect Positive IC50 170
tentoxin 10 nM spinach CF1(-ɛ)-ATPase affect Positive Ki 170
tentoxin 30-60 μM TF1-ATPase affect Positive Ki 170
tentoxin 8-10 nM spinach CF1(-ɛ)-ATPase affect Positive Kd 170
efrapeptins affect Positive 170
azide affect Positive 170
resveratrol affect Positive 170
N,N'-dicyclohexylcarbodiimide 0.2 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase affect Positive IC50 170
N,N'-dicyclohexylcarbodiimide 1-5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase affect Positive IC50 170
N,N'-dicyclohexylcarbodiimide 200 μMa in less than 5 min and at ∼40 μMa in 30 min R. rubrum F1-ATPase affect Positive 170
N,N'-dicyclohexylcarbodiimide 1.9 μg/mg protein C. fasciculata SMP-ATPase affect Positive IC50 170
N,N'-dicyclohexylcarbodiimide 1 mol DCCD/mol F1 EF1-ATPase affect Positive 95% inhibition 170
N,N'-dicyclohexylcarbodiimide 30 μM membrane-bound EF0F1-ATPase affect Positive maximal 70-80% inhibition 170
N,N'-dicyclohexylcarbodiimide 5 μM C. thermoaceticum membrane-bound F0F1-ATPase affect Positive 47% inhibition 170
N,N'-dicyclohexylcarbodiimide 2 mol inhibitor bound/mol F1 bovine heart MF1-ATPase affect Positive 97% inhibition 170
N,N'-dicyclohexylcarbodiimide 1 mol inhibitor/mol F0 bovine heart SMP-ATPase affect Positive maximal inhibition 170
N,N'-dicyclohexylcarbodiimide 2 mol inhibitor/mol F0 bovine heart H+-translocation affect Positive maximal inhibition 170
N,N'-dicyclohexylcarbodiimide 1 mol inhibitor/mol F0 E. coli membrane H+-translocation affect Positive maximal inhibition 170
N,N'-dicyclohexylcarbodiimide affect Positive 170
woodward's reagent k affect Positive 170
woodward's reagent k affect Positive 170
cyclophilin D affect Positive 171
Rotenone 0.07 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Rotenone 0.04 nmol/mg bovine mitochondria NADH–O2 decrease Positive IC50 94
Deguelin 4.2 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 95
Piericidin A 0.06 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Piericidin A 0.03 nmol/mg bovine mitochondria NADH:O2 decrease Positive IC50 94
Ubicidin-3 0.17 nmol/mg bovine mitochondria NADH:O2 decrease Positive IC50 96
Rolliniastatin-1 0.03 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 98
rolliniastatin-2 0.06 nmol/mg bovine mitochondria NADH–Q-1 decrease Positive IC50 98
Otivarin 0.2 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 98
phenoxan 0.04 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Thiangazole 0.04 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
myxalamid pi 15 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
phenalamid a2 0.6 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Aurachin a 8.0 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Myxothiazol 20 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
stigmatellin 100 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
TDS 40 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
aureothin 0.3 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 94
Cochlioquinone b 83 nmol/mg bovine mitochondria NADH:O2 decrease Positive IC50 100
strobilurin a >100 nmol/mg bovine mitochondria NADH–Q decrease Positive IC50 99
pterulone 36 μM bovine mitochondria NADH:O2 decrease Positive IC50 101
Capsaicin 20–30 μM bovine mitochondria NADH–Q decrease Positive IC50 102
Capsaicin 20–30 μM bovine mitochondria NADH:O2 decrease Positive IC50 102
Rhein 30 μM bovine mitochondria NADH:O2 decrease Positive IC50 104
Papaverine 5 μM bovine mitochondria NADH–Q-1 decrease Positive IC50 30
Ubiquinone-2 2 μM bovine mitochondria NADH–Q-1 decrease Positive IC50 106
Ubiquinone-3 40 μM bovine mitochondria NADH–Q decrease Positive IC50 107
Idebenone 0.4 μM NADH–Q decrease Positive IC50 106
Pyridaben 2.4 nM NADH–Q-1 decrease Positive IC50 108
Fenpyroximate 4.6 nM NADH–Q-1 decrease Positive IC50 108
Fenpyroximate 18 nM NADH–Q decrease Positive IC50 103
Tebufenpyrad 6 nM NADH–Q-1 decrease Positive IC50 108
fenazaquin 20 nM NADH–Q-1 decrease Positive IC50 109
Benzimidazole 3 nM NADH–Q decrease Positive IC50 94
cyhalothrin 0.6 μM NADH–DQ decrease Positive IC50 110
6-chloro-benzothiadiazole 0.1 mM NADH:O2 decrease Positive IC50 111
2M-TIO 40 μM NADH–Q-1 decrease Positive IC50 112
amytal 0.2 mM NADH–Q-1 decrease Positive IC50 112
meperidine 0.1 mM NADH–Q-1 decrease Positive IC50 108
MPP+ 0.3 mM NADH:O2 decrease Positive IC50 114
MPP+ 2–4 mM NADH–Q decrease Positive IC50 115
4'-decyl-mpp+ 1.7 μM NADH:O2 decrease Positive IC50 115
MQ18 0.2 μM NADH–Q-1 decrease Positive IC50 116
2-methylharmine 0.18 mM NADH:O2 decrease Positive IC50 117
TIQ 2 mM NADH:O2 decrease Positive IC50 118
Haloperidol 3 μM NADH–Q-1 decrease Positive IC50 119
HPP+ 15 μM NADH–Q-1 decrease Positive IC50 119
Dequalinium Chloride 11 μM NADH:O2 decrease Positive IC50 120
Cinnarizine 5–10 μM NADH–Q-1 decrease Positive IC50 121
para-nonylphenol 20 μM NADH–Q decrease Positive IC50 108
Catechol 0.4 mM NADH–Q decrease Positive IC50 108
CCCP 85 μM NADH–Q-1 decrease Positive IC50 108
Erythrosin 5'-iodoacetamide 20 nM NADH–O2 decrease Positive IC50 126
Safranine 17 μM NADH–Q decrease Positive IC50 127
dioc5(3) 1.5 μM NADH–Q decrease Positive IC50 127
dioc6(3) 80 nM NADH–O2 decrease Positive IC50 126
Diphenyleneiodonium chloride 0.23 μM NADH–Q-1c decrease Positive IC50 128
N,N'-dicyclohexylcarbodiimide 0.1 mM NADH–Q-1 decrease Positive IC50 129
o-phenanthroline 0.25 mM NADH–Q decrease Positive IC50 130
Leucinostatin 11 μg/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
Leucinostatin 2 μg inhibitor/ml spinach chloroplast decrease Positive IC50 132
Leucinostatin 0.1-0.4 μg/mg protein rat isolated liver mitochondria decrease Positive 133
efrapeptins 0.56 mol/mol F1 bovine heart MF1-ATPase decrease Positive IC50 134
efrapeptins 70 ng/ml C. asciculate MF1-ATPase decrease Positive IC50 135
efrapeptins 0.3 μM human umbilical vein endothelial cell, nonmitochondrial ATP synthase decrease Positive IC50 136
efrapeptins 0.5 μg/ml R. rubrum chromatophores decrease Positive IC50 137
efrapeptins 0.05-0.5 μg of inhibitor/mg protein T. pyriformis SMP-ATPase decrease Positive IC50 138
efrapeptins 21.5 μM EF1-ATPase decrease Positive ki 139
efrapeptins 10 nM bovine heart MF1-ATPase decrease Positive kd 134
efrapeptins 2.4 mol inhibitor/mol enzyme bovine heart SMP-ATPase decrease Positive complete inhibition 134
resveratrol 27.7 μM rat brain SMP, ATP synthesis decrease Positive 140
resveratrol 14 μM rat liver MF1-ATPase decrease Positive 141
resveratrol 19 μM rat brain M F0F1-ATPase decrease Positive 140
resveratrol 6.4 μM bovine bovine heart MF1-ATPase decrease Positive 142
resveratrol 2 μM human human umbilical vein endothelial cell, nonmitochondrial ATP synthase, ATP synthesis decrease Positive 136
Diethylstilbestrol 10 μM rat liver MF0F1-ATPase decrease Positive 143
Diethylstilbestrol 10-25 μM rat brain MF0F1-ATPase decrease Positive 141
SITS ∼1.3 μM V. parahaemolyticus F0F1-ATPase decrease Positive 144
SITS 25 μM V. parahaemolyticus F1-ATPase decrease Positive 95% inhibition 145
DIDS 20.9 μM rat liver MF1ATPase decrease Positive 146
quercetin 5 kmol/mol bovine heart MF1-ATPase decrease Positive IC50 147
quercetin 85 μM bovine heart MF1-ATPase decrease Positive IC50 148
quercetin 180 μM bovine heart SMP-ATPase decrease Positive IC50 148
quercetin 50 μM rat brain F0F1-ATPase decrease Positive IC50 140
quercetin 3 μM rat liver F1-ATPase decrease Positive IC50 141
quercetin 2 kmol/mola spinach CF1-ATPase decrease Positive 147
quercetin 2.6 μg/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
quercetin 0.2 mM pig heart MF1-ATPase decrease Positive Ki 149
quercetin 27 μM bovine heart MF1-ATPase decrease Positive Kd 147
quercetin 5 μM C. thermoaceticum membrane-bound F0F1-ATPase decrease Positive 46% inhibition 150
kaempferol 55 μM rat brain MF0F1-ATPase decrease Positive IC50 140
morin 60 μM  rat brain MF0F1-ATPase decrease Positive IC50 140
apigenin 105 μM  rat brain MF0F1-ATPase decrease Positive IC50 140
genistein 55 μM rat brain MF0F1-ATPase decrease Positive IC50 140
genistein 50 μM rat liver F1-ATPase decrease Positive 10% inhibition 141
Biochanin A 65 μM  rat brain MF0F1-ATPase decrease Positive IC50 140
Daidzein 127 μM  rat brain MF0F1-ATPase decrease Positive IC50 151
Oligomycin 152 μg inhibitor/mg protein E. coli membrane vesicle decrease Positive IC50 152
Oligomycin 7.1 μg inhibitor/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
Oligomycin 2.0-3.0 μg inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 153
Oligomycin 0.3 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
Oligomycin 15 ng inhibitor/mg protein N. crassa SMP-ATPase decrease Positive Ki 155
Oligomycin 0.21 μM bovine heart MF0F1-ATPase decrease Positive Ki 156
Oligomycin 0.4 μg inhibitor/mg protein bovine heart SMP-ATPase decrease Positive 95% inhibition 157
Oligomycin 0.5 μg/ml rat liver SMP-ATPase decrease Positive 75% inhibition 158
peliomycin 4.5 μg inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 153
venturicidin B 9 μg inhibitor/mg protein E. coli membrane vesicle decrease Positive IC50 152
venturicidin B 11 μg inhibitor/mg protein E. coli membrane-bound ATPase decrease Positive IC50 152
venturicidin B 0.13 μg inhibitor/mg protein decrease Positive IC50 153
venturicidin B 0.06-0.18 (A and B) and 11.0 (X) μg inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 159
venturicidin B 5-11 μg inhibitor/mg protein T. pyriformis decrease Positive IC50 138
venturicidin B 3.0 μg/mg protein C. asciculate SMP-ATPase decrease Positive IC50 131
venturicidin B 0.5 μM spinach thylakoids decrease Positive IC50 160
venturicidin B 0.5 μM spinach thylakoids, ATPase decrease Positive IC50 160
ossamycin 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase decrease Positive IC50 153
ossamycin 46 μg of inhibitor/mg protein E. coli membrane vesicle decrease Positive IC50 152
ossamycin 8 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
apoptolidin 4-5 μM S. cerevisiae membrane-bound F0F1-ATPase decrease Positive Ki 161
apoptolidin 18 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
cytovaricin 1 μM human NCI-60 cell lines, F0F1-ATPase decrease Positive IC50 154
cytovaricin 0.4 μM S. cerevisiae membrane-bound F0F1-ATPase decrease Positive Ki 161
ossamycin 0.8 μM 60 human cancer cell lines of the National Cancer Institute decrease Positive mean 184
Perhexiline affect Positive 227
atpenin a5 bovine heart mitochondria affect Positive 192
Carboxin bovine heart mitochondria affect Positive 192
Thenoyltrifluoroacetone bovine heart mitochondria affect Positive 192
HQNO bovine heart mitochondria affect Positive 192
Chlorpromazine inhibit Positive 197
Haloperidol inhibit Positive 197
Clozapine inhibit Positive 197
Nefazodone inhibit Positive 197
Metformin inhibit Positive 197
Phenformin inhibit Positive 197
Troglitazone inhibit Positive 197
Rosiglitazone inhibit Positive 197
Pioglitazone inhibit Positive 197
Oligomycin 8 nM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
aurovertin B 1.5 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.05 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.05 3
Amiodarone 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Chlorpromazine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Chlorpromazine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Chlorpromazine 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Diclofenac 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.01 3
gefitinib 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.05 3
gefitinib 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.001 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.01 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.01 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.001 3
Nefazodone 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.01 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
paroxetine 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex I activity decrease Positive p < 0.01 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.001 3
Simvastatin 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive p < 0.001 3
Tamoxifen 50 μM bovine heart mitochondria Measurement of complex V activity decrease Positive p < 0.001 3
Tamoxifen 15 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 15 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 26.6 μM bovine heart mitochondria Measurement of complex IV activity decrease Positive IC50 3
Tamoxifen 8.1 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Tamoxifen 4 μM bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 3
Tamoxifen 1.6 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Tamoxifen 30 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 30 μM bovine heart mitochondria Measurement of complex II + III activity decrease Positive IC50 3
Tamoxifen 29 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Tamoxifen 26 μM bovine heart mitochondria Measurement of complex V activity decrease Positive IC50 3
Zidovudine Interfere Positive 307
Acyclovir Interfere Positive 307
Ganciclovir Interfere Positive 307
Zalcitabine Interfere Positive 307
tetracyclines decrease Positive 307
Ciprofloxacin decrease Positive 307
Clozapine decrease Positive 307
sertraline rat brain mitochondria decrease Positive 307
Fluoxetine rat brain mitochondria decrease Positive 307
sertraline rat liver mitochondria decrease Positive 307
Fluoxetine rat liver mitochondria decrease Positive 307
atorvastatin C2C12 myoblasts affect Positive 180
Cerivastatin 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds decrease Positive 180
pitavastatin 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds decrease Positive 180
lovastatin 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds decrease Positive 180
Simvastatin 100uM C2C12 myoblasts Measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds. The lactone forms of the indicated statins were included in the assay medium at their cytotoxic EC50 concentration for measurement of their effect on the catalytic capacity. decrease Positive 180
Simvastatin 200uM bovine heart mitochondria Reduction of the CIII cytochromes c1 and b was determined spectrophotometrically in bovine heart mitochondria. affect Positive p < 0.01 180
Metformin 5 mM 24 hours human MCF7 Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF7 Meassurement of coupled respiration decrease Positive p < 0.05 172
Metformin 5 mM 24 hours human MCF7 Meassurement of coupled respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours mouse NMuMG Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours mouse NT2196 Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF10A Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 0.5 mM 24 hours human MCF7 Meassurement of mitochondrial respiration decrease Positive p < 0.05 172
Metformin 66 mM Bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 15
buformin 11.3 mM Bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 15
Phenformin 1.2 mM Bovine heart mitochondria Measurement of complex I activity decrease Positive IC50 15