D0475 | para-nonylphenol
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| UNCOUPLING | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | increase | 53 | |||
| ELECTRON TRANSPORT CHAIN | affect | 53 | ||||||
| ELECTRON TRANSPORT CHAIN | 20 μM | NADH–Q | decrease | IC50 | 108 | |||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| NADH:ubiquinone reductase | 20 μM | NADH–Q | inhibitor | IC50 | 108 | |||
| quinol | antagonist | 53 | ||||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 637 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 447 of 637 companies. For more detailed information, please visit ECHA C&L website Of the 10 notification(s) provided by 190 of 637 companies with hazard statement code(s): H302 (98.95%): Harmful if swallowed [Warning Acute toxicity, oral] H314 (99.47%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H318 (54.74%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H361 (95.26%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H400 (78.42%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (79.47%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] H411 (20%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P201, P202, P260, P264, P270, P273, P280, P281, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P321, P330, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Warning |
Aggregated GHS information provided by 444 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H315 (99.32%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (99.32%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H361fd: Suspected of damaging fertility Suspected of damaging the unborn child [Warning Reproductive toxicity] |
P201, P202, P260, P264, P270, P280, P281, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P321, P330, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H302: Harmful if swallowed [Warning Acute toxicity, oral] H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard] H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] |
P201, P202, P260, P264, P270, P273, P280, P281, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P321, P330, P363, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Warning |
H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | oral | 580mg/kg (580mg/kg) | National Technical Information Service. Vol. OTS0573098, | |
| rabbit | LD50 | skin | 2140uL/kg (2.14mL/kg) | American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. | |
| mouse | LD50 | oral | 1231mg/kg (1231mg/kg) | National Technical Information Service. Vol. AD-A067-313, | |
| (C9)Alkylated phenol | 1-(4-Hydroxyphenyl)nonane | 104-40-5 |
| 211947-56-7 | 3-06-00-02067 (Beilstein Handbook Reference) | 4-NP |
| 4-Nonyl Phenol-13C6 | 4-Nonyl-Phenol | 4-Nonylphenol, PESTANAL(R), analytical standard |
| 4-Nonylphenol, analytical standard | 4-Nonylphenol, certified reference material, TraceCERT(R); | 4-n-Nonyl phenol |
| 4-n-Nonylphenol | 4-n-Nonylphenol 10 microg/mL in Acetonitrile | 4-n-Nonylphenol 10 microg/mL in Cyclohexane |
| 4-n-Nonylphenol 100 microg/mL in Cyclohexane | 4-n-Nonylphenol, 85% | 4-n-Nonylphenol, 98% |
| 4-nonyl phenol | 4-nonylphenol | 68081-86-7 |
| AKOS015888197 | BDBM50410532 | BIDD:ER0006 |
| BIDD:PXR0002 | BRN 2047450 | BSPBio_002543 |
| C-33468 | C14550 | C9-Alkylated phenol |
| CAS-104-40-5 | CC-20192 | CCG-39613 |
| CCRIS 1251 | CHEBI:34440 | CHEMBL153062 |
| CTK0I0829 | DSSTox_CID_1857 | DSSTox_GSID_33836 |
| DSSTox_RID_79098 | DTXSID5033836 | DivK1c_006720 |
| EINECS 203-199-4 | EINECS 268-359-8 | FT-0619310 |
| HSDB 5359 | I03GBV4WEL | IGFHQQFPSIBGKE-UHFFFAOYSA-N |
| J-001167 | KBio1_001664 | KBio2_002530 |
| KBio2_005098 | KBio2_007666 | KBio3_002043 |
| KBioGR_001263 | KBioSS_002539 | KSC180Q2T |
| LMPK15010001 | LS-375 | MCULE-5930378829 |
| MFCD00002396 | NCGC00090918-01 | NCGC00090918-02 |
| NCGC00090918-03 | NCGC00090918-05 | NCGC00090918-06 |
| NCGC00090918-07 | NCGC00090918-08 | NCGC00257420-01 |
| NCGC00258793-01 | Nonylphenol (mixed) | P-NONYLPHENOL (ENDOCRINE DISRUPTER) |
| Para-nonyl phenol | Phenol, 4-nonyl- | Phenol, nonyl derivs. |
| Phenol, p-nonyl- | Q4545806 | RTR-000982 |
| SBB059316 | SCHEMBL15887 | SPBio_001903 |
| SPECTRUM330085 | SR-05000002459 | SR-05000002459-1 |
| ST50827096 | STL453644 | SpecPlus_000624 |
| Spectrum2_001832 | Spectrum3_000872 | Spectrum4_000712 |
| Spectrum5_002066 | Spectrum_001973 | TR-000982 |
| TRA0078987 | Tox21_201241 | Tox21_303647 |
| UNII-I03GBV4WEL | ZINC1850497 | nonyl-phenol |
| p -n -Nonylphenol | p-Nonylphenol | p-n-Nonylphenol |
| p-nonyl phenol | p-nonyl-phenol | para Nonyl phenol |
| para-Nonylphenol |